NDLI: Numerical simulation on the effects of drug-eluting stents with different bending angles on hemodynamics and drug distribution

Content Provider	Springer Nature Link
Author	Chen, Yu Xiong, Yan Jiang, Wentao Wong, Man Sang Yan, Fei Wang, Qingyuan Fan, Yubo
Copyright Year	2016
Abstract	Implantation of drug-eluting stents in curved blood vessels may cause changes in hemodynamics and drug distribution, and even provoke in-stent restenosis. Due to the complexity of building three-dimensional (3-D) curved stent model, few studies have gone through such numerical simulations. In this study, three virtual stent models with different bending angles (0°, 30° and 90°) were developed to numerically investigate the distribution of wall shear stress (WSS) and drug concentration. The results showed that (1) the low-WSS regions in the inner bend of the stent models increased with the bending angles; (2) the drug concentration differed between the inner and outer bends of the stents but irrespective to the changes of bending angle; (3) the pattern of drug concentration for the curved stents found similar to that of the straight stents, and the phenomenon, ‘proximal part low and distal part high’ in the drug concentration showed in both the straight and curved stents. The increase in bending angles from 30° to 90° had little effect on the WSS and drug concentration; however, the largest effect of the curved stents was the remarkable difference of drug concentration between the inner and outer bends of the stents—about 20 %. Hence, it is feasible that quick analysis focused on the straight stents instead of the curved stents.
Starting Page	1859
Ending Page	1870
Page Count	12
File Format	PDF
ISSN	01400118
Journal	Medical and Biological Engineering and Computing
Volume Number	54
Issue Number	12
e-ISSN	17410444
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Drug-eluting stents Curved artery Wall shear stress Drug concentration flow Human Physiology Biomedical Engineering Imaging Radiology Computer Applications
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications

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