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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Lopez-Andres, N. Laurent, C. Fortuno, M. A. Labat, C. Diez, J. Zannad, F. Lacolley, P. Rossignol, P. |
| Abstract | Cardiotrophin-1 (CT-1), a cytokine belonging to the interleukin-6 family, exerts proliferative and secretory effects in vascular smooth muscle cells. We aimed to investigate the functional and morphological vascular changes induced by chronic CT-1 administration in rats and its involvement in the arterial phenotype of CT-1-null mice. A) CT-1 (20 mg/Kg, IP) was administrated to Wistar rats for six weeks (n = 10/group). B) 2 year-old wild-type (WT) (n = 12) and CT-1-null mice (n = 12) were studied. Vascular structure and function were evaluated by an echo-tracking device. Circumferential wall stress, incremental elastic modulus (Einc), media cross-sectional area and pulse wave velocity (PWV) were measured. Aortic wall collagen, elastin and fibronectin contents were determined using immunohistochemistry, RT-PCR and Western blot. A) Neither vehicle nor CT-1 treatment modified BP. The Einc/wall stress curve from CT-1-treated was shifted to the left as compared with vehicle group. CT-1-treated rats also showed increased media cross sectional area (p < 0.01), collagen content (p < 0.01) and fibronectin expression (p < 0.01). B) CT-1-null mice presented an increased wall stress (p < 0.05) and Einc (p < 0.05) as compared with WT mice. Media cross sectional area, collagen and fibronectin content were reduced (p <0.05) in mice lacking CT-1. Normotensive rats subjected to CT-1 overloading developed impaired vascular function, characterized by an increment in arterial stiffness accompanied by an augmented media thickness and extracellular matrix production. Accordingly, CT-1-null mice presented a reduced arterial stiffness and a reduced media thickness and collagen content. Our data show that CT-1 is a key player in arterial thickness and stiffness. |
| Related Links | https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2010.10.168.pdf |
| Ending Page | 147 |
| Page Count | 1 |
| Starting Page | 147 |
| File Format | HTM / HTML |
| ISSN | 18764401 |
| DOI | 10.1016/j.artres.2010.10.168 |
| Journal | Artery Research |
| Issue Number | 4 |
| Volume Number | 4 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2010-12-02 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Medicine/Public Health |
| Content Type | Text |
| Resource Type | Synopsis |
| Subject | Physiology (medical) Physiology |
| Journal Impact Factor | 0.9/2023 |
| 5-Year Journal Impact Factor | 0.7/2023 |
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