NDLI: HS-23, a standardized extract of the dried flower buds of Lonicera japonica, has no major impact on drug transporters and on the pharmacokinetics of ceftriaxone and levofloxacin in rats

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HS-23, a standardized extract of the dried flower buds of Lonicera japonica, has no major impact on drug transporters and on the pharmacokinetics of ceftriaxone and levofloxacin in rats

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Journal of Pharmaceutical Investigation : Volume 45

Journal of Pharmaceutical Investigation : Volume 44

Journal of Pharmaceutical Investigation : Volume 43

Journal of Pharmaceutical Investigation : Volume 42

HS-23, a standardized extract of the dried flower buds of Lonicera japonica, has no major impact on drug transporters and on the pharmacokinetics of ceftriaxone and levofloxacin in rats

Content Provider	Springer Nature Link
Author	Kim, Young Mok Hong, Sung Woon Song, Im Sook Lee, Hye Suk Kwon, Mihwa Kwon, Soon Sang Yeon, Sung Hum Kim, Ju Hyun
Copyright Year	2015
Abstract	Concurrent administration of herbal drugs that modulate drug transporter activities can cause herb–drug interactions in the process of the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. For this reason, regulatory agencies have instituted guidelines for the investigation of potential herb–drug interactions during the drug development process. Therefore, the purpose of this study was to investigate the herb–drug interaction potential of HS-23, an extract of the dried flower buds of Lonicera japonica, which is being evaluated for use in the treatment of sepsis in a phase II clinical study. The inhibitory effects of HS-23 on the transport functions of organic cation transporter (OCT)1, OCT2, organic anion transporter (OAT)1, OAT3, organic anion transporting polypeptide (OATP)1B1, OATP1B3, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) were investigated in HEK293 and LLC-PK1 cells. The effects of HS-23 on the pharmacokinetics of ceftriaxone and levofloxacin, common combination drugs for sepsis treatment were also examined in rats. HS-23 (up to 100 μg/mL) did not inhibit the in vitro transport activities of OCT1/2, OAT1/3, OATP1B1/1B3, P-gp, and BCRP or the pharmacokinetics of ceftriaxone and levofloxacin in vivo after a single intravenous dose of 40 mg/kg. In conclusion, HS-23 may not have significant herb–drug interactions with the prevalently used ceftriaxone and levofloxacin, in rats even at its effective dose.
Starting Page	13
Ending Page	19
Page Count	7
File Format	PDF
ISSN	20935552
Journal	Journal of Pharmaceutical Investigation
Volume Number	46
Issue Number	1
e-ISSN	20936214
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-09-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Levofloxacin Transporters Ceftriaxone Herb–drug interaction HS-23 Biomedicine general Lonicera japonica
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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HS-23, a standardized extract of the dried flower buds of Lonicera japonica, has no major impact on drug transporters and on the pharmacokinetics of ceftriaxone and levofloxacin in rats