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Formulation, optimization and evaluation of microemulsion based gel of Butenafine Hydrochloride for topical delivery by using simplex lattice mixture design

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Formulation, optimization and evaluation of microemulsion based gel of Butenafine Hydrochloride for topical delivery by using simplex lattice mixture design

Content Provider	Springer Nature Link
Author	Barot, Tularam Rajesh, K. S. Jha, Lalit Lata Rao, Shruti
Copyright Year	2015
Abstract	The aim of the present investigation was to develop and evaluate Butenafine Hydrochloride loaded microemulsion based gel for treatment of fungal infection. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of Capmul MCM as oil, Cremophor RH 40 as surfactant and Transcutol HP as co-surfactant. Composition of microemulsion system was optimized using simplex lattice mixture design including the concentration of oil, Surfactant co-surfactant ratio (Smix) and water (independent variables) and the % transmittance and globule size of microemulsion (response variables). The physicochemical properties of the optimized microemulsion were investigated. Microemulsion was incorporated into 1 % carbopol 934P gel and the ex vivo drug permeation of gel was also investigated. The results showed that the optimized microemulsion formulation was composed of Capmul MCM oil (5 %, w/w), Cremophor RH 40/Transcutol HP (43.333 %, w/w) and water (51.667 %, w/w). The mean globule diameter was 108.8 nm. The conclusion was that the release controlling ability of microemulsion containing gel formulation was significantly improved in comparison to commercial cream. Skin irritation study was also performed and it shows no irritation on rat skin after 24 h of application. Microbiological assay of Butenafine Hydrochloride was performed where it shows better zone of inhibition than marketed formulation.
Starting Page	1
Ending Page	12
Page Count	12
File Format	PDF
ISSN	20935552
Journal	Journal of Pharmaceutical Investigation
Volume Number	46
Issue Number	1
e-ISSN	20936214
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-08-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Simplex lattice mixture design Pseudo ternary phase diagrams Skin irritation study Microemulsion based gel Ex vivo study Biomedicine general Drug deposition study
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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Formulation, optimization and evaluation of microemulsion based gel of Butenafine Hydrochloride for topical delivery by using simplex lattice mixture design

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