NDLI: Isoflavones as modulators of adenosine monophosphate-activated protein kinase

Content Provider	Springer Nature Link
Author	Shin, Soon Young Ahn, Seunghyun Jung, Hyeryoung Kim, Beum Soo Lim, Yoongho Lee, Young Han
Copyright Year	2016
Abstract	Adenosine monophosphate-activated protein kinase (AMPK) is expressed in all eukaryotic cells and can therefore be found in vertebrates, invertebrates, and plants. Since AMPK participates in the regulation of homeostasis on various levels, small compounds that can modulate AMPK activity could be valuable research tools. Several flavonoids can modulate AMPK. Here we investigated the modulatory effect of 37 isoflavones on AMPK activity using an in vitro kinase assay. Because the relationship between the structural properties of flavonoids and their modulatory activities has not been elucidated yet, we used comparative molecular field analysis to derive the structural conditions for modulation of AMPK activity. The molecular binding mode of isoflavones to AMPK was elucidated using in silico docking studies. The findings presented here can aid in the design of new modulators with better specificity for AMPK.
Starting Page	217
Ending Page	225
Page Count	9
File Format	PDF
ISSN	24680834
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	59
Issue Number	2
e-ISSN	24680842
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-01-29
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Isoflavone Quantitative structure-activity relationship Adenosine monophosphate-activated protein kinase Kinase Applied Microbiology In silico docking Biological Techniques Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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Flavonoids activating adenosine monophosphate-activated protein kinase

Erratum to: Flavonoids activating adenosine monophosphate-activated protein kinase

Flavones with inhibitory effects on glycogen synthase kinase 3β

Changes of isoflavone profiles in Cheonggukjang with Lentinus edodes

Biotransformation of isoflavones by Aspergillus niger and Cunninghamella elegans

Characterization of Isoflavones Accumulation in Developing Leaves of Soybean (Glycine max) Cultivars

Exploring quantitative structure–activity relationship (QSAR) models for some biologically active catechol structures using PC-LS-SVM and PC-ANFIS

Changes in phenolic compounds (Isoflavones and Phenolic acids) and antioxidant properties in high-protein soybean (Glycine max L., cv. Saedanbaek) for different roasting conditions

Erratum to: Flavonoids activating adenosine monophosphate-activated protein kinase

Isoflavones as modulators of adenosine monophosphate-activated protein kinase

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Flavonoids activating adenosine monophosphate-activated protein kinase

Erratum to: Flavonoids activating adenosine monophosphate-activated protein kinase

Flavones with inhibitory effects on glycogen synthase kinase 3β

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Biotransformation of isoflavones by Aspergillus niger and Cunninghamella elegans

Characterization of Isoflavones Accumulation in Developing Leaves of Soybean (Glycine max) Cultivars

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Isoflavones as modulators of adenosine monophosphate-activated protein kinase