NDLI: Simple extraction method requiring no cleanup procedure for the detection of minocycline residues in porcine muscle and milk using triple quadrupole liquid chromatography-tandem mass spectrometry

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Simple extraction method requiring no cleanup procedure for the detection of minocycline residues in porcine muscle and milk using triple quadrupole liquid chromatography-tandem mass spectrometry

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Journal of the Korean Society for Applied Biological Chemistry : Volume 59, Issue 1, February 2016

Journal of the Korean Society for Applied Biological Chemistry : Volume 58

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Simple extraction method requiring no cleanup procedure for the detection of minocycline residues in porcine muscle and milk using triple quadrupole liquid chromatography-tandem mass spectrometry

Content Provider	Springer Nature Link
Author	Cho, Soo Min Shim, Jae Han Park, Jin A Kim, Seong Kwan Cho, Sang Hyun Yi, Hee Jeong, Daun Abd El Aty, A. M. Kim, Jin Suk Zhang, Dan Shin, Ho Chul
Copyright Year	2016
Abstract	A versatile analytical method was developed for simple detection of minocycline residues in porcine muscle and milk using liquid chromatography-triple quadrupole tandem mass spectrometry (LC/MS/MS) with electrospray ionization. Samples were extracted with a mixture of acetonitrile and ethyl acetate (2:1, v/v), and then defatted using n-hexane. No cleanup procedure was deemed necessary. Minocycline was separated on a reversed-phase analytical column using a combination of 0.1 % formic acid in water (A) and 0.1 % formic acid in acetonitrile (B) as the mobile phase. Matrix-matched calibration showed good linearity over a concentration range of 10–60 μg/kg with a determination coefficient (R $^{ 2 }$) of 0.9727. Fortified porcine and milk samples having concentrations equivalent to and double the limit of quantification (LOQ = 10 ng/g), respectively, yielded recovery ranges between 83.02 and 8.03 % and relative standard deviations <18 %. Samples collected from a large market located in Seoul, Korea, tested negative for minocycline residue. These results show that a combination of acetonitrile and ethyl acetate can effectively extract minocycline from porcine muscle and milk without solid-phase extraction, a step usually required for cleanup before analysis. The developed method is simple, sensitive, and can be extrapolated to other food animal products that are rich in protein and fats.
Starting Page	297
Ending Page	303
Page Count	7
File Format	PDF
ISSN	24680834
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	59
Issue Number	2
e-ISSN	24680842
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-02-03
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Tandem mass spectrometry Porcine muscle Liquid-phase extraction Minocycline Applied Microbiology Biological Techniques Bioorganic Chemistry Milk
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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