NDLI: Inhibitory effects of purpurogallin on the endothelial protein C receptor shedding in vitro and in vivo

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Inhibitory effects of purpurogallin on the endothelial protein C receptor shedding in vitro and in vivo

Content Provider	Springer Nature Link
Author	Ku, Sae Kwang Bae, Jong Sup Lee, In Chul
Copyright Year	2013
Abstract	Endothelial cell protein C receptor (EPCR) plays important roles in the regulation of blood coagulation and inflammation. Activity of EPCR is markedly changed by ectodomain cleavage and released as soluble protein (sEPCR). EPCR can be shed from the cell surface, and this is mediated by tumor necrosis factor-α converting enzyme (TACE). Purpurogallin (PPG) plays an important role in inhibiting glutathione S-transferase and xanthine oxidase as well as effective in the cell protection of several cell types. Here, we investigated the effects of PPG on phorbol-12-myristate 13-acetate (PMA), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and on cecal ligation and puncture (CLP)-mediated EPCR shedding and underlying mechanisms. Human umbilical vein endothelial cells pretreated with PPG (0, 5, 10, 20 or 50 μg/mL) for 6 h and exposed to PMA (1 μM) for 1 h, and CLP-operated mice were administrated with PPG. Data showed that treatment with PPG resulted in potent inhibition of PMA, TNF-α, IL-1β, and CLP-induced EPCR shedding by suppression of TACE expression. In addition, PPG reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases 1/2, and c-Jun N-terminal kinase. These results suggest the potential for use of PPG as an anti-sEPCR shedding reagent against PMA and CLP-mediated EPCR shedding.
Starting Page	519
Ending Page	524
Page Count	6
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	56
Issue Number	5
e-ISSN	2234344X
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-10-31
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	purpurogallin phorbol-12-myristate 13-acetate Applied Microbiology Biological Techniques shedding endothelial cell protein C receptor Bioorganic Chemistry cecal ligation and puncture
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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Inhibitory effects of purpurogallin on the endothelial protein C receptor shedding in vitro and in vivo

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Inhibitory effects of purpurogallin on the endothelial protein C receptor shedding in vitro and in vivo