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| Content Provider | Springer Nature Link |
|---|---|
| Author | Feki, Hafed Rebai, Tarek Feki, Abdelfatteh Elleuch, Jiheun Tounsi, Slim Keskes, Hassib Oudadesse, Hassane Jebahi, Samira pellen, Pascal |
| Copyright Year | 2013 |
| Abstract | Strontium (Sr) compounds have become increasingly popular in the field of osteoporosis treatment. However, the quality of new bone after implantation of strontium-containing bioceramics has yet to be investigated. In the present study, the newly formed bone tissue around strontium-doped bioactive glass (BG-Sr) implants was characterized. BG-Sr was implanted in the femoral condyl of ovariectomised rats (OVX). The resected bone was prepared for analysis using several physico-chemical and biological assays such as Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, and histomorphometry. BG-Sr biomaterial favored calcium phosphate layer integration on the surface of the glass and offered better bioactivity. Moreover, the histomorphometric analysis demonstrated that BV/TV, N. Ob were significantly higher in BG-Sr treated rats groups than those of BG groups. However, Ob. S/BS, and OV/BV were significantly lower in BG-Sr treated rats groups than those of BG groups. The (Oc.S/BS) was significantly decreased in BG-Sr groups, when compared with that of BG rat groups. On the other hand, the MS/BS had not significantly decreased in the BG-Sr treated rats groups when compared with that of BG groups, however; it was significantly higher when compared with control and OVX groups. These findings suggest that BG-Sr can be used as an inhibitory therapeutic potential of osteoporosis by delivering strontium to stimulate new bone remodeling. |
| Starting Page | 533 |
| Ending Page | 540 |
| Page Count | 8 |
| File Format | |
| ISSN | 17382203 |
| Journal | Journal of the Korean Society for Applied Biological Chemistry |
| Volume Number | 56 |
| Issue Number | 5 |
| e-ISSN | 2234344X |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-10-31 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | bioactive glass strontium effect Applied Microbiology bone regeneration Biological Techniques ions release osteoporosis Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry, Genetics and Molecular Biology |
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