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Different biological targets for resiniferatoxin and phorbol 12-myristate 13-acetate.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Driedger, P. E. Blumberg, Peter M. |
| Copyright Year | 1980 |
| Abstract | The phorbol-related diterpene ester resiniferatoxin is at least 100-fold more inflammatory for the mouse ear than is the potent tumor promoter phorbol 12-myristate 13-acetate but is nonpromoting. We report here that resiniferatoxin is 100- to 1000-fold less active than is phorbol 12-myristate 13-acetate in in vitro assays with both chicken and mouse fibroblasts. These results suggest that resiniferatoxin and phorbol 12-myristate 13-acetate have different primary target sites (receptors) and provide further evidence that the fibroblast target may be homologous to that involved in promotion. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 7189445 |
| Journal | Medline |
| Volume Number | 40 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://cancerres.aacrjournals.org/content/canres/40/5/1400.full.pdf |
| Journal | Cancer research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
