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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lee, A Yeong Choi, Goya Moon, Byeong Cheol Cheon, Myeong Sook Yu, So Yeon Kim, Seung Ju Choo, Byung Kil Kim, Ho Kyoung Yasukawa, Ken Yoon, Taesook |
| Copyright Year | 2003 |
| Abstract | The roots of both Aralia continentalis and Angelica biserrata, known as /lsDokwhal/rs in Korea, have been used widely as a traditional oriental medicine to treat inflammation and thrombosis. However, the pharmacological differences between A. continentalis and A. biserrata have not been fully established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts of A. continentalis (ACE) and A. biserrata (ABE) on the production of inflammatory mediators and secondary swelling from chemically induced ear edema. In RAW264.7 macrophages, both ACE and ABE significantly inhibited the release of nitric oxide, prostaglandin E$_{2}$, interlukin-1beta, and tumor necrosis factor-alpha in a dose dependent manner. In addition, the swelling from TPA-induced edema in mouse ears was reduced by ACE and ABE. Overall, ACE showed stronger activities than ABE in vitro and in vivo. Our results indicate that A. continentalis roots possess stronger anti-inflammatory activity than A. Biserrata roots. |
| Starting Page | 157 |
| Ending Page | 162 |
| Page Count | 6 |
| File Format | |
| ISSN | 17382203 |
| Journal | Journal of the Korean Society for Applied Biological Chemistry |
| Volume Number | 52 |
| Issue Number | 2 |
| e-ISSN | 2234344X |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2003-01-01 |
| Publisher Place | New York |
| Access Restriction | Subscribed |
| Subject Keyword | inflammatory mediators Applied Microbiology Biological Techniques anti-inflammation TPA-induced ear edema Angelica biserrata Aralia continentalis Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry, Genetics and Molecular Biology |
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