NDLI: Different shapes of Al$_{2}$O$_{3}$ particles induce differential cytotoxicity via a mechanism involving lysosomal destabilization and reactive oxygen species generation

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Different shapes of Al$_{2}$O$_{3}$ particles induce differential cytotoxicity via a mechanism involving lysosomal destabilization and reactive oxygen species generation

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Journal of the Korean Society for Applied Biological Chemistry : Volume 58, Issue 2, April 2015

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Different shapes of Al$_{2}$O$_{3}$ particles induce differential cytotoxicity via a mechanism involving lysosomal destabilization and reactive oxygen species generation

Content Provider	Springer Nature Link
Author	Chung, Namhyun Joo, Yong Hoon Pak, Pyo June Kim, Joong Su Kim, Byung Il
Copyright Year	2015
Abstract	The biological effects of nano- and micro-sized Al$_{2}$O$_{3}$ particles are hypothesized to differ according to the shapes as well as the sizes of the particles. Thus, the mechanisms of interleukin (IL)-1β production and the association between the shape of the Al$_{2}$O$_{3}$ particle and its cytotoxicity in macrophage-like THP-1 cells were investigated using particles with three different shapes [N-Al$_{2}$O$_{3}$ (<30 nm), S-Al$_{2}$O$_{3}$ (2–4 nm × 100–800 nm), L-Al$_{2}$O$_{3}$ (2–4 nm × 2800 nm)]. Levels of IL-1β production and cytotoxicity were concentration-dependent and were in the following order: S-Al$_{2}$O$_{3}$ > N-Al$_{2}$O$_{3}$ > L-Al$_{2}$O$_{3}$. Stimulus of THP-1 cells by Al$_{2}$O$_{3}$ particles led to lysosomal destabilization, generation of intracellular reactive oxygen species (ROS), and subsequent release of cathepsin B. The magnitude of the stimulus was dependent on the shapes and aspect ratios of the particles. Additional results suggested that caspase-1 (NALP3 inflammasome) activation and IL-1β production followed cathepsin B release. In addition, the cell death induced by Al$_{2}$O$_{3}$ particles was closely related with cathepsin B leakage. The mode of cell death was necrotic as much as apoptotic. We conclude that Al$_{2}$O$_{3}$ particles induce different levels of IL-1β production and cytotoxicity depending on their particle shapes or aspect ratios. The current finding may support the development of safe forms of Al$_{2}$O$_{3}$ particles.
Starting Page	433
Ending Page	442
Page Count	10
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	58
Issue Number	3
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2015-03-24
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	Reactive oxygen species Lysosomal destabilization Cathepsin B Applied Microbiology Cytotoxicity Biological Techniques Interleukin-1beta Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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