NDLI: Biological evaluation of the diterpenes from Croton macrostachyus

Content Provider	Springer Nature Link
Author	Terfa, Akalu Shin, Soon Young Dinku, Worku Tesso, Hailemichael Lim, Yoongho Yong, Yeonjoong Dekebo, Aman Lee, Young Han
Copyright Year	2017
Abstract	To clarify whether the seeds of Croton macrostachyus can induce apoptosis, its methanolic extract was first subjected to a clonogenic survival assay, which measures long-term cytotoxic effects. Since it showed cytotoxicity on HCT116 human colon cancer cell lines, further separation was performed, and two single diterpene compounds were obtained. One of them was identified to be a novel compound, methyl 2-(furan-3-yl)-6a,10b-dimethyl-4-oxo-2,4,4a,5,6,6a,10a,10b-octahydro-1H-benzo[f]isochromene-7-carboxylate, based on the interpretation of the nuclear magnetic resonance spectroscopic and mass spectrometric data. Its treatment of HCT116 cells with 50 μg/mL triggered the cleavage of both initiator caspase-9 and effector caspase-7. Moreover, the cleavage of poly (ADP-ribose) polymerase, a substrate of caspase-7, increased after 24 h of treatment. These results demonstrate that this compound exerts antitumor activity by triggering caspase-mediated apoptotic cell death in HCT116 human colon cancer cells.
Starting Page	615
Ending Page	621
Page Count	7
File Format	PDF
ISSN	24680834
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	60
Issue Number	6
e-ISSN	24680842
Language	English
Publisher	Springer Netherlands
Publisher Date	2017-09-04
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Clonogenicity Croton macrostachyus Seed Applied Microbiology Biological Techniques Crotomacrine Bioorganic Chemistry Apoptosis
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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