NDLI: In silico designing of some agonists of toll-like receptor 5 as a novel vaccine adjuvant candidates

Content Provider	Springer Nature Link
Author	Ovchinnikov, Roman S. Ranjbar, Mohammad Mehdi Farhadi, Tayebeh
Copyright Year	2016
Abstract	Infectious diseases are an important cause of fatality worldwide and administration of vaccines could provide long-lasting protection against responsible infection. Incorporating of adjuvants to vaccine formulations can enhance the effectiveness of antigens. This study proposes an in silico approach for designing of some flagellin derivatives as adjuvant candidates and investigation of their interaction with toll-like receptor 5 (TLR5). Docking analysis showed that the flagellin derivative from Escherichia coli (named Adj2) possesses the best interaction tendency with the TLR5. The Adj2 was inserted to N terminal of a previously designed antigen against Salmonella enterica (named SAL) to construct a fusion protein. Docking analysis showed that the binding to TLR5 occurs on the Adj2 domain of the fusion protein, which completely lacks SAL domain. It proposes that the SAL domain may be prospective for eliciting appropriate immune responses. Besides, according to the total free energy, the fusion protein reveals the mutual affinity to TLR5. Overall, successful in silico modeling was demonstrated to be a hopeful strategy for designing robust vaccine adjuvants targeting TLR5.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISSN	21926662
Journal	Network Modeling Analysis in Health Informatics and Bioinformatics
Volume Number	5
Issue Number	1
e-ISSN	21926670
Language	English
Publisher	Springer Vienna
Publisher Date	2016-10-13
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infection Computational Biology/Bioinformatics Adjuvant designing Health Informatics Flagellin derivative Bioinformatics Applications of Graph Theory and Complex Networks
Content Type	Text
Resource Type	Article
Subject	Urology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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