NDLI: Bee venom inhibits 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced mouse skin inflammation

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Bee venom inhibits 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced mouse skin inflammation

Oriental Pharmacy and Experimental Medicine : Volume 11

Bee venom inhibits 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced mouse skin inflammation

Content Provider	Springer Nature Link
Author	Chung, Hwan Suck Kim, Hyung Shik
Copyright Year	2011
Abstract	Bee venom (BV) has been used to treat diseases such as arthritis, rheumatism and pain in many countries. Although BV has recently been used as an additive of functional cosmetics, there is no evidence of the effects of BV on skin inflammation or disease. Here, we show that BV patch attachment or intra-peritoneal injection inhibited in vivo acute inflammation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) using the mouse ear model of inflammation. When we examined the TNF-alpha and IL-1 beta mRNA expression in BV treated ear samples by real time PCR, even though BV treatment had no significant effects, it inhibited TNF-alpha and IL-1 beta mRNA expression when compared to samples treated with TPA alone. BV also inhibited edema (based on ear weight) and inhibited neutrophil infiltration (based on myeloperoxidase (MPO) activity measured as a neutrophil marker). Taken together, these results showed that BV exerted an anti-inflammatory effect in vivo and was beneficial in an animal model of skin inflammation. These results suggest that BV might be beneficial as a topical agent for the treatment of skin inflammation.
Starting Page	75
Ending Page	79
Page Count	5
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	12
Issue Number	1
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-12-22
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Bee venom 12-O-tetradecanoyl-phorbol-13-acetate Skin inflammation Ear edema Pharmacy Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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