NDLI: Syzygium cumini (L.) skeels seed extract ameliorates in vitro and in vivo oxidative potentials of the brain cerebral cortex of alcohol-treated rats : Syzygium cumini (L.) skeels seed extract inhibits oxidative potentials of brain

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Syzygium cumini (L.) skeels seed extract ameliorates in vitro and in vivo oxidative potentials of the brain cerebral cortex of alcohol-treated rats : Syzygium cumini (L.) skeels seed extract inhibits oxidative potentials of brain

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Oriental Pharmacy and Experimental Medicine : Volume 11

Syzygium cumini (L.) skeels seed extract ameliorates in vitro and in vivo oxidative potentials of the brain cerebral cortex of alcohol-treated rats : Syzygium cumini (L.) skeels seed extract inhibits oxidative potentials of brain

Content Provider	Springer Nature Link
Author	Hossain, Shahdat Rahaman, Asiqur Nahar, Taslima Basunia, Mafroz Ahmed Mowsumi, Ferdousi Rahman Uddin, Borhan Shahriar, Masum Mahmud, Ishtiaq
Copyright Year	2011
Abstract	We investigated the effect of Syzygium cumini(L.) Skeels seed extract on the oxidative stress of brain cortical tissues of alcohol-treated rats. The in vitro antioxidative effect of methnolic S. cumini seed extract was initially compared with those of the buytylated hydroxyl toluene (BHT) and Vitamin C, by determining their DPPH-free radical scavenging activity. The S. cumini seed extract exhibited stronger free radical scavenging activity than those of the BHT and Vitamin C. Cortex homogenates were then directly incubated with 15% ethanol and/or Fenton’s reagent (H$_{2}$O$_{2}$ + Fe$_{2}$SO$_{4}$) to induce in vitro oxidative stress in the absence or presence of S. cumini seed extract . The S. cumini seed extract significantly reduced the levels of lipid peroxide (LPO) in the cortical homogenates. Twenty four rats were then divided into four groups: Control, S. cumini seed extract (SE)-administered, 15% ethanol-fed (EtOH) and EtOH + SE rats. The oral administration of the extract (400 mg/kg BW.day) for 8 weeks significantly (P < 0.05) decreased the levels of LPO in the cortex of the EtOH + SE rats, suggesting that S. cumini seed not only scavenged the DPPH-free radicals and obstructed the ethanol/Fenton’s reagents-induced in vitro oxidative stress of the cortical tissues but also reduced their in vivo formation. These results suggest that S. cumini seed could be used as a potential antioxidant therapy for alcoholics.
Starting Page	59
Ending Page	66
Page Count	8
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	12
Issue Number	1
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-11-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Syzygium cumini seed Alcohol Free radical Lipid peroxidation Brain cortex Antioxidant Pharmacy Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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