NDLI: Comparative antihyperglycaemic and antihyperlipidemic effect of Origanum majorana extracts in NIDDM rats

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Oriental Pharmacy and Experimental Medicine : Volume 11

Comparative antihyperglycaemic and antihyperlipidemic effect of Origanum majorana extracts in NIDDM rats

Content Provider	Springer Nature Link
Author	Pimple, B. P. Kadam, P. V. Patil, M. J.
Copyright Year	2011
Abstract	Diabetes mellitus is a metabolic disorder prevailing throughout the world irrespective of age, sex and race. The present study deals with phytochemical, antioxidant, antihyperglycaemic and antihyperlipidemic potential of Origanum majorana (OM) leaves. Various extracts of OM were used for the study such as, hydrodistilled volatile oil (OMO), petroleum ether extract (OMPE), methanolic extract (OMM) and aqueous extract (OMW). Three doses of each extract viz. 100, 200 and 400 mg/kg p.o. were used for the study. Streptozotocin, STZ (65 mg/Kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non insulin dependent diabetes mellitus (NIDDM) in rats. Various biochemical markers of blood and tissue origin were estimated. The results were statistically analyzed by ANOVA followed by Dunnett’s test. Glibenclamide, a well known antidiabetic drug, was used as a standard. Volatile oil (OMO, 200 and 400 mg/kg p.o.) and methanolic extract (OMM, 200 and 400 mg/kg p.o.) exhibited dose dependent significant (p < 0.01) antihyperglycaemic activity. The aqueous (OMW, 200 and 400 mg/kg p.o.) had moderate (p < 0.05) effect on blood sugar level. The volatile oil (OMO, 100 mg/kg p.o.) was less significant (p < 0.05) in lowering the elevated triglyceride and cholesterol levels. Whereas; methanolic (OMM, 200 and 400 mg/kg p.o.) and aqueous (OMW, 200 and 400 mg/kg p.o.) extracts substantially (p < 0.01) showed antihyperlipidemic effect. From this study, it was concluded that the volatile oil and methanolic extract of Origanum majorana leaves could prove to be beneficial in management of NIDDM and its associated lipid imbalance.
Starting Page	41
Ending Page	50
Page Count	10
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	12
Issue Number	1
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-11-24
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Antioxidant Antihyperglycaemic Glibenclamide Origanum majorana Streptozotocin Pharmacy Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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