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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ishiwata, Isamu Ono, Isao Kiguchi, Kazushige Ishiwata, Chieko Soma, Masayuki Ishikawa, Hiroshi |
| Copyright Year | 2005 |
| Abstract | A cell line designated HOTHC was established from an anaplastic carcinoma (giant cell type) of the thyroid gland of 80-year-old woman. The HOTHC line grew rapidly in multilayer without contact inhibition, and more than 120 serial passages were made within 27 months. The cells were spindle or polygonal in shape and revealed neoplastic and pleomorphic features. These cells were characterized as containing coloid droplets and poorly developed rough-endoplasmic reticulum in the cytoplasm. Doubling time was about 24 hours and plating efficiency was about 70%. The karyotype exhibits hyperploidy and marker chromosomes, and the modal chromosome number ranged between 77–90. The HOTHC cells were transplanted into the subcutis of BALB/c nude mice and produced anaplatic carcinomas (giant cell type) resembling the original tumor.The HOTHC cells produced colony stimulating factor (CSF) and caused granulocytosis in the mice. |
| Starting Page | 163 |
| Ending Page | 169 |
| Page Count | 7 |
| File Format | |
| ISSN | 09147470 |
| Journal | Human Cell |
| Volume Number | 18 |
| Issue Number | 3 |
| e-ISSN | 17490774 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-08-06 |
| Publisher Place | Tokyo |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Colony stimulating factor thyroid carcinoma cell line Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cancer Research |
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