NDLI: Loss of integrin α3 expression is associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells

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Loss of integrin α3 expression is associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells

Content Provider	Springer Nature Link
Author	Suzuki, Nao Higashiguchi, Atsushi Hasegawa, Yuko Matsumoto, Hiroshi Oie, Shinji Orikawa, Kimiko Ezawa, Sachiko Susumu, Nobuyuki Miyashita, Ki ichi Aoki, Daisuke
Copyright Year	2005
Abstract	Among various types of surface epithelial ovarian carcinoma, clear cell adenocarcinoma often has a particularly poor prognosis even when diagnosed in stage I. It is resistant to existing anticancer drugs and appears to have different biological properties to other histological types of ovarian cancer.The present study was conducted using cell lines derived from ovarian clear cell adenocarcinoma in order to identify genes associated with the acquisition of malignant potential by this type of cancer. Two cell lines derived from ovarian clear cell adenocarcinoma (RMG-I and RMG-V), with different levels of invasive potential in an invasion assay, were used. DNA fragments were extracted from the band showing differences in the level of expression by RT-PCR with fluorescent differential display. A total of 56 different DNA base sequences were determined by direct sequencing. Primers were established using these base sequences and the level of expression in each cancer cell line was determined by real-time PCR Integrin a3, the gene of which is present on chromosome 17q, was identified. It was also detected by a microarray analysis as one of the molecules showing a different level of expression between the two cell lines. Then the pattern of integrin α3 expression was investigated using immunocytochemical staining, and was found to differ between the two cell lines. The findings obtained using these cell lines derived from ovarian clear cell adenocarcinoma indicate that integrin α3 may associated with the acquisition of malignant potential by clear cell adenocarcinoma.
Starting Page	147
Ending Page	155
Page Count	9
File Format	PDF
ISSN	09147470
Journal	Human Cell
Volume Number	18
Issue Number	3
e-ISSN	17490774
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-06
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ovarian clear cell adenocarcinoma integrin α3 RMG-I RMG-V Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cancer Research

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