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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ishikawa, Takaki Zhu, Bao Li Miyaishi, Satoru Ishizu, Hideo Maeda, Hitoshi |
| Copyright Year | 2005 |
| Abstract | Major objectives in forensic gerontology are physical and mental disorders during aging. which can be caused by various factors involving nutrition and stress, often accompanied by dysfunction in the neuroendocrine systems including the hypophysis. The objective of the present study was to investigate the histopathological changes in the adenohypophysis in elderly subjects using autopsy materials. Hypophyses with a scaphoid shape (group S: 16 males and 4 females: mean age. 78.6 years) and a normal one (group C: 30 males and 20 females: mean age. 65.2 years) were compared. Incidence of the scaphoid-shaped hypophysis mildly increased with age, being 17% in the elderly over 65 years of age. The weight of the pituitary gland in group S (0.42 ± 0.1 g) was lower than that of group C (0.65 ± 0.2 g). The degree of fibrosis was higher in group S (31.6% ± 5.4%) than in group C (18.3% ± 6.3%). lmmunohistochemical staining showed no significant differences in the proportion of the ACTH cells and the TSH cells between the two groups (p>0.05). However, there was an increase in the proportion of gonadotrophs. prolactin cells, and S-100-containing cells in group S and a decrease in that of GH cells (p<0.05). These findings may be associated with reduced anabolic, gonadal and hepatic functions due to malnutrition. |
| Starting Page | 157 |
| Ending Page | 162 |
| Page Count | 6 |
| File Format | |
| ISSN | 09147470 |
| Journal | Human Cell |
| Volume Number | 18 |
| Issue Number | 3 |
| e-ISSN | 17490774 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-08-06 |
| Publisher Place | Tokyo |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | human pituitary immunohistochemistry malnutrition morphology neuroendocrine Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cancer Research |
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