NDLI: Dual-mixed HIV-1 coreceptor tropism and HIV-associated neurocognitive deficits

Content Provider	Springer Nature Link
Author	Morris, Sheldon R. Woods, Steven Paul Deutsch, Reena Little, Susan J. Wagner, Gabriel Morgan, Erin E. Heaton, Robert K. Letendre, Scott L. Grant, Igor Smith, Davey M.
Copyright Year	2013
Abstract	HIV coreceptor usage of CXCR4 (X4) is associated with decreased CD4+ T-cell counts and accelerated disease progression, but the role of X4 tropism in HIV-associated neurocognitive disorders (HAND) has not previously been described. This longitudinal study evaluated data on 197 visits from 72 recently HIV-infected persons who had undergone up to four sequential neurocognitive assessments over a median of 160 days (IQR, 138–192). Phenotypic tropism testing (Trofile ES, Monogram, Biosciences) was performed on stored blood samples. Multivariable mixed model repeated measures regression was used to determine the association between HAND and dual-mixed (DM) viral tropism, estimated duration of infection (EDI), HIV RNA, CD4 count, and problematic methamphetamine use. Six subjects (8.3 %) had DM at their first neurocognitive assessment and four converted to DM in subsequent sampling (for total of 10 DM) at a median EDI of 10.1 months (IQR, 7.2–12.2). There were 44 (61.1 %) subjects who demonstrated HAND on at least one study visit. HAND was associated with DM tropism (odds ratio, 4.4; 95 % CI, 0.9–20.5) and shorter EDI (odds ratio 1.1 per month earlier; 95 % CI, 1.0–1.2). This study found that recency of HIV-1 infection and the development of DM tropism may be associated with HAND in the relatively early stage of infection. Together, these data suggest that viral interaction with cellular receptors may play an important role in the early manifestation of HAND.
Starting Page	488
Ending Page	494
Page Count	7
File Format	PDF
ISSN	13550284
Journal	Journal of NeuroVirology
Volume Number	19
Issue Number	5
e-ISSN	15382443
Language	English
Publisher	Springer US
Publisher Date	2013-09-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HIV-associated neurocognitive disorders Coreceptor tropism Methamphetamine Neurosciences Virology Infectious Diseases Immunology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dual-mixed HIV-1 Coreceptor Tropism and HIV-Associated Neurocognitive Deficits

An initial screening for HIV-associated neurocognitive disorders of HIV-1 infected patients in China

Subtype associations with HIV-associated neurocognitive disorder in China

A comparison of performance-based measures of function in HIV-associated neurocognitive disorders

Neurocognitive functioning in acute or early HIV infection

Complement and HIV-I infection/HIV-associated neurocognitive disorders

Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil

Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders

Relevance of lipopolysaccharide levels in HIV-associated neurocognitive impairment: the Neuradapt study

Dual-mixed HIV-1 coreceptor tropism and HIV-associated neurocognitive deficits

Similar Documents

Dual-mixed HIV-1 Coreceptor Tropism and HIV-Associated Neurocognitive Deficits

An initial screening for HIV-associated neurocognitive disorders of HIV-1 infected patients in China

Subtype associations with HIV-associated neurocognitive disorder in China

A comparison of performance-based measures of function in HIV-associated neurocognitive disorders

Neurocognitive functioning in acute or early HIV infection

Complement and HIV-I infection/HIV-associated neurocognitive disorders

Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil

Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders

Relevance of lipopolysaccharide levels in HIV-associated neurocognitive impairment: the Neuradapt study

Dual-mixed HIV-1 coreceptor tropism and HIV-associated neurocognitive deficits