NDLI: Physical exercise is associated with less neurocognitive impairment among HIV-infected adults

Content Provider	Springer Nature Link
Author	Dufour, Catherine A. Marquine, Maria J. Fazeli, Pariya L. Henry, Brook L. Ellis, Ronald J. Grant, Igor Moore, David J.
Copyright Year	2013
Abstract	Neurocognitive impairment (NCI) remains prevalent in HIV infection. Randomized trials have shown that physical exercise improves NCI in non-HIV-infected adults, but data on HIV-infected populations are limited. Community-dwelling HIV-infected participants (n = 335) completed a comprehensive neurocognitive battery that was utilized to define both global and domain-specific NCI. Participants were divided into “exercise” (n = 83) and “no exercise” (n = 252) groups based on whether they self-reported engaging in any activity that increased heart rate in the last 72 h or not. We also measured and evaluated a series of potential confounding factors, including demographics, HIV disease characteristics, substance use and psychiatric comorbidities, and physical functioning. Lower rates of global NCI were observed among the exercise group (15.7 %) as compared to those in the no exercise group (31.0 %; p < 0.01). A multivariable logistic regression controlling for potential confounds (i.e., education, AIDS status, current CD4+ lymphocyte count, self-reported physical function, current depression) showed that being in the exercise group remained significantly associated with lower global NCI (odds ratio = 2.63, p < 0.05). Similar models of domain-specific NCI showed that exercise was associated with reduced impairment in working memory (p < 0.05) and speed of information processing (p < 0.05). The present findings suggest that HIV-infected adults who exercise are approximately half as likely to show NCI as compared to those who do not. Future longitudinal studies might be best suited to address causality, and intervention trials in HIV-infected individuals will determine whether exercise can prevent or ameliorate NCI in this population.
Starting Page	410
Ending Page	417
Page Count	8
File Format	PDF
ISSN	13550284
Journal	Journal of NeuroVirology
Volume Number	19
Issue Number	5
e-ISSN	15382443
Language	English
Publisher	Springer US
Publisher Date	2013-08-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HIV/AIDS Mild neurocognitive impairment Physical exercise Cognition Lifestyle Neuropsychology Neurosciences Virology Infectious Diseases Immunology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience

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