NDLI: Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Viral load and muscle tone are correlated

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Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Viral load and muscle tone are correlated

Content Provider	Springer Nature Link
Author	Zunt, J. R. Montano, S. M. Beck, I. Alarcón, J. O. V. Frenkel, L. M. Bautista, C. T. Price, R. Longstreth, W. T.
Copyright Year	2006
Abstract	Human T-lymphotropic virus type 1 (HTLV-1) infections are associated with varying degrees of HTLV-1 viral load and spasticity. Increased viral load is associated with higher risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The authors performed a cross-sectional study of 24 people with HAM/TSP in Lima, Perú, to determine if higher HTLV-1 viral load was correlated with increased muscle tone, measured with a device providing quantitative spasticity assessment (QSA). Median HTLV-1 viral load was 17.0 copies/100 peripheral blood mononuclear cells and QSA value was 39.9 Newton-meters/radian. HTLV-1 viral load was significantly correlated with QSA value (Spearman rho = .48, P = .02), suggesting viral load may play a role in expression of symptomatic neurologic disease. Longitudinal studies are needed to determine if treatments that reduce viral load will reduce muscle tone.
Starting Page	466
Ending Page	471
Page Count	6
File Format	PDF
ISSN	13550284
Journal	Journal of NeuroVirology
Volume Number	12
Issue Number	6
e-ISSN	15382443
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	human T-cell lymphotropic virus type 1 (HTLV-1) myelopathy tropical spastic paraparesis Neurosciences Virology Infectious Diseases Immunology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience

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Human T-lymphotropic virus type 1–associated myelopathy/tropical spastic paraparesis: Viral load and muscle tone are correlated

Human T-lymphotropic virus type 1–associated myelopathy/tropical spastic paraparesis: Viral load and muscle tone are correlated

Subacute progression of human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP)

Quantitative assessment of spasticity in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.

Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

Subacute progression of human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Viral load and muscle tone are correlated

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