NDLI: All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells

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Tumor Biology : Volume 31, Issue 5, October 2010

Tumor Biology : Volume 31, Issue 4, August 2010

Tumor Biology : Volume 31, Issue 1, Supplement,August 2010

Tumor Biology : Volume 31, Issue 3, June 2010

Tumor Biology : Volume 31, Issue 2, April 2010

Tumor Biology : Volume 31, Issue 1, January 2010

All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells

Content Provider	Springer Nature Link
Author	Xu, Ying Wang, Tianyou Tang, Ruihong Tang, Suoqin
Copyright Year	2010
Abstract	The high expression of folate receptor (FR) on cancer cells might be a potential target for cancer therapy. In this study, the FR-β expression and the modulation effect of all-trans retinoic acid (ATRA) in a number of cancer cell lines were analyzed. The gateway of ATRA activity on FR-β expression was further studied by a panel of retinoid activators and inhibitors. The results revealed that ATRA was capable of upregulating the expression of FR-β protein in KG-1 cells in a dosage-dependent manner, not in KG-1a, NB4, HL60, 293, L1210, JAR, and Hela cells. FR-β mRNA expression in KG-1 cells was higher when ATRA was present in culture medium at 10$^{−6}$ mol/L for 5 days, and it went down to baseline when ATRA was removed from the medium, vice versa. The upregulation of FR-β expression in KG-1 cells by ATRA was not associated with cell proliferation and differentiation. In addition, activators of retinoid acid receptor (RAR)α and RARγ, CD336, and CD2781 also induced FR-β expression. The induction of FR-β expression by CD336 could be inhibited by RARγ antagonist CD2665; RARβ agonist CD-417 and CD-2314 as well as retinoid X receptor (RXR) agonist LG100364 could not induce FR-β expression. These results indicate that ATRA within a certain range of concentration could reversibly induce the expression of FR-β in a dosage- and cell type-dependent manner, and its action in KG-1 cells might be associated with the signal transduction of retinoid receptor RARα and RARγ, rather than RARβ and RXRs.
Starting Page	589
Ending Page	595
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	31
Issue Number	6
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-07-15
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	ATRA Folate receptor Target therapy Leukemia Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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