NDLI: P21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells

Please wait, while we are loading the content...

PI3-kinase/Wnt association mediates COX-2/PGE$_{2}$ pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac

Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China

RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis

Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer

A combination treatment with SAHA and ad-p63/p73 shows an enhanced anticancer effect in HNSCC

Length of lymphangiogenesis in the rectal tissues distal to rectal cancer

The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer

Tumor Biology : Volume 31, Issue 5, October 2010

Tumor Biology : Volume 31, Issue 4, August 2010

Tumor Biology : Volume 31, Issue 1, Supplement,August 2010

Tumor Biology : Volume 31, Issue 3, June 2010

Tumor Biology : Volume 31, Issue 2, April 2010

Tumor Biology : Volume 31, Issue 1, January 2010

P21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells

Content Provider	Springer Nature Link
Author	Wang, Xia Gong, Wei Qing, Haitao Geng, Yan Wang, Xinying Zhang, Yongsheng Peng, Liang Zhang, Hongquan Jiang, Bo
Copyright Year	2010
Abstract	p21-activated kinase 5 (PAK5) is a recently identified member of the group B PAK family. The PAK proteins are effectors of the small GTPase Cdc42 and Rac1 and are known to regulate cell motility and activate cell-survival signaling pathways. Especially, the mitochondrial localization of PAK5 is vital to its effects on apoptosis and cell survival. Previously, we demonstrated that PAK5 expression increased significantly during the malignant progression of colorectal carcinoma (CRC) and that PAK5 promoted CRC metastasis by regulating CRC cell adhesion and migration. In the present study, we aim to investigate the role of PAK5 in camptothecin-induced apoptosis and its potential mechanism of action. Our results showed that overexpression of PAK5 inhibited camptothecin-induced apoptosis by inhibiting the activity of caspase-8 in CRC cells. Accordingly, knockdown of PAK5 in LoVo cells resulted in increased apoptosis. Mechanistically, we found that PAK5 directly phosphorylated Bad on serine 112 and indirectly led to phosphorylation of serine 136 via the Akt pathway. In conclusion, our study revealed previously unappreciated inhibitory role of PAK5 in camptothecin-induced apoptosis, thus suggesting PAK5 as a novel therapeutic target in CRC.
Starting Page	575
Ending Page	582
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	31
Issue Number	6
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-06-22
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	PAK5 Colorectal carcinoma Apoptosis Camptothecin Bad Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in