NDLI: Downregulated expression of DIXDC1 in hepatocellular carcinoma and its correlation with prognosis

Content Provider	Springer Nature Link
Author	Zhou, Senjun Shen, Jiliang Lin, Shuang Liu, Xiaolong Xu, Ming Shi, Liang Wang, Xianfa Cai, Xiujun
Copyright Year	2016
Abstract	Dishevelled-Axin domain containing 1 (DIXDC1) is a DIX (Dishevelled-Axin) domain possessing protein that acts as a positive regulator of the Wnt pathway. Although DIXDC1 has been investigated in several cancers, it has not yet been studied in human hepatocellular carcinoma (HCC). The purpose of the current study was to investigate the expression pattern of DIXDC1 and assess the clinical significance of DIXDC1 expression in HCC patients. Data containing three independent investigations from Oncomine database demonstrated that DIXDC1 mRNA was downregulated in HCC compared with matched non-cancerous tissues. Similar results were also obtained in 25 paired HCC tissues and corresponding non-cancerous tissues by qPCR and Western blot analysis. Additionally, another independent set of 140 pairs of HCC specimens was evaluated for DIXDC1 expression by IHC and demonstrated that reduced expression of DIXDC1 in 50.7 % (71/140) of HCC tissues was significantly correlated with tumor size (p = 0.024), tumor differentiation (p < 0.001), tumor thrombi (p = 0.019), TNM stage (p = 0.019), and BCLC stage (p = 0.008). Importantly, Kaplan–Meier survival and Cox regression analyses were executed to evaluate the prognosis of HCC patients and found that DIXDC1 protein expression was one of the independent prognostic factors for overall survival of HCC patients.
Starting Page	13607
Ending Page	13616
Page Count	10
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-07-28
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	DIXDC1 Hepatocellular carcinoma Prognosis Survival Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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