NDLI: CA27.29 as a tumour marker for risk evaluation and therapy monitoring in primary breast cancer patients

Content Provider	Springer Nature Link
Author	Rack, Brigitte Jückstock, Julia Trapp, Elisabeth Weissenbacher, Tobias Alunni Fabbroni, Marianna Schramm, Amelie Widschwendter, Peter Lato, Krisztian Zwingers, Thomas Lorenz, Ralf Tesch, Hans Schneeweiss, Andreas Fasching, Peter Mahner, Sven Beckmann, Matthias W. Lichtenegger, Werner Janni, Wolfgang
Copyright Year	2016
Abstract	Several trials showed that tumour markers are associated with an impaired prognosis for breast cancer. Whether earlier treatment can improve the course of the disease remains controversial. The SUCCESS Trial compares FEC (500/100/500)-docetaxel (100) vs. FEC (500/100/500)-docetaxel/gemcitabine (75/2000) as well as 2 vs. 5 years of zoledronate in high-risk primary breast cancer patients. In 2669 patients, CA27.29 was measured before and after chemotherapy with the ST AIA-PACK CA27.29 reagent for the AIA-600II automated enzyme immunoassay (Tosoh Bioscience, Belgium). Values above 31 U/ml were considered positive. Of the patients, 7.6 % (n = 202, mean 19, range 3–410) and 19.1 % (n = 511, mean 21, range 3–331) had elevated marker levels before and after chemotherapy, respectively. Of the patients, 4.9 and 78 % showed elevated and low CA27.29, respectively, at both time points. After treatment, 35 % of the pre-therapy positive patients were negative, and 15 % of the initially negative patients became positive. The correlation between both time points was significant (p < 0.0001). No correlations among nodal status, grading, hormonal status, HER2 status and CA27.29 levels were found. However, tumour size (p = 0.02), older age (p < 0.001) and post-menopausal status (p = 0.006) were significantly associated with higher CA27.29 levels. Before treatment, the prevalence of elevated CA27.29 was equally distributed between both treatment arms, whereas after chemotherapy, 13.7 % of the patients in the FEC-doc arm showed an increased level vs. 25.4 % of the patients in the FEC-doc/gemcitabine arm (p < 0.0001). However, we could not show a significant association between the G-CSF application (yes vs. no) and CA27.29 status before/after chemotherapy (p = 0.75). These results indicate a close relationship between CA27.29 levels and tumour mass. Increased values after the completion of chemotherapy might be attributed to treatment effects and should be considered with caution.
Starting Page	13769
Ending Page	13775
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-08-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Breast cancer Tumour marker CA27.29 Chemotherapy Treatment monitoring Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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