NDLI: Molecular targets of curcumin for cancer therapy: an updated review

Content Provider	Springer Nature Link
Author	Kasi, Pandima Devi Tamilselvam, Rajavel Skalicka Woźniak, Krystyna Nabavi, Seyed Fazel Daglia, Maria Bishayee, Anupam Pazoki toroudi, Hamidreza Nabavi, Seyed Mohammad
Copyright Year	2016
Abstract	In recent years, natural edible products have been found to be important therapeutic agents for the treatment of chronic human diseases including cancer, cardiovascular disease, and neurodegeneration. Curcumin is a well-known diarylheptanoid constituent of turmeric which possesses anticancer effects under both pre-clinical and clinical conditions. Moreover, it is well known that the anticancer effects of curcumin are primarily due to the activation of apoptotic pathways in the cancer cells as well as inhibition of tumor microenvironments like inflammation, angiogenesis, and tumor metastasis. In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-β catenin, mTOR and so on. Clinical studies also suggested that either curcumin alone or as combination with other drugs possess promising anticancer effect in cancer patients without causing any adverse effects. In this article, we critically review the available scientific evidence on the molecular targets of curcumin for the treatment of different types of cancer. In addition, we also discuss its chemistry, sources, bioavailability, and future research directions.
Starting Page	13017
Ending Page	13028
Page Count	12
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-07-28
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Anticancer Curcumin Polyphenol Turmeric Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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