NDLI: Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets

Content Provider	Springer Nature Link
Author	Hadler Olsen, Elin Winberg, Jan Olof Uhlin Hansen, Lars
Copyright Year	2013
Abstract	Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most cancers, there are increased levels of one or several members of the matrix metalloproteinases (MMPs). This is a family of proteolytic enzymes that are involved in many phases of cancer progression, including angiogenesis, invasiveness, and metastasis. It has therefore been expected that MMPs could serve as both diagnostic and prognostic markers in cancer patients, but despite a huge number of studies, it has been difficult to establish MMPs as cancer biomarkers. In the present paper, we assess some of the challenges associated with MMP research as well as putative reasons for the conflicting data on the value of these enzymes as diagnostic and prognostic markers in cancer patients. We also review the prognostic value of a number of MMPs in patients with lung, colorectal, breast, and prostate cancers. The review also discusses MMPs as potential target molecules for therapeutic agents and new strategies for development of such drugs.
Starting Page	2041
Ending Page	2051
Page Count	11
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-17
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Matrix metalloproteinase Cancer Biomarkers Drug design Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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