NDLI: Imaging and therapy of hSSTR2-transfected tumors using radiolabeled somatostatin analogs

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Imaging and therapy of hSSTR2-transfected tumors using radiolabeled somatostatin analogs

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Tumor Biology : Volume 34, Issue 3, June 2013

Tumor Biology : Volume 34, Issue 2, April 2013

Tumor Biology : Volume 34, Issue 1, February 2013

Tumor Biology : Volume 33

Tumor Biology : Volume 32

Tumor Biology : Volume 31

Imaging and therapy of hSSTR2-transfected tumors using radiolabeled somatostatin analogs

Content Provider	Springer Nature Link
Author	Wang, Zhe Ma, Wenhui Wang, Jing Deng, Jinglan Yuan, Menghui Zhao, Mingxuan Jia, Lintao Yang, Weidong Zhang, Rui Qin, Weiwei Chu, Dake Li, Guoquan
Copyright Year	2013
Abstract	The aim of this study was to introduce human somatostatin receptors subtype-2 (hsstr2) gene into A549 lung carcinoma cells in order to investigate the role of these receptors, and to observe the lethal effect of $^{131}$I-RC-160 (RC-160, vapreotide, an analog of somatostatin) on transfected cells through tumor scintigraphy. Clones overexpressing SSTR2 were selected for radioligand-receptor binding assay and assessment of $^{125}$I-RC-160 internalization. The methylthiazolyl tetrazolium test was used to observe the lethal effect of $^{131}$I-RC-160, Na$^{131}$I, and RC-160 on hSSTR2-transfected A549 cells (A549-hSSTR2). Planar imaging was performed with a gamma camera equipped with pinhole collimator in nude mice bearing both A549-hSSTR2 tumors overexpressing SSTR2 and A549-pcDNA3 (pcDNA3-transfected A549 cells) tumors as control. Images were obtained at 0.5, 6, and 24 h after injection of 3.7 × 10$^{6}$ Bq $^{99m}$Tc-RC-160 via the tail vein. The inhibitory effects of $^{131}$I-RC-160, RC-160, and Na$^{131}$I on the tumors were recorded by measuring the tumor volumes. At the end of the study, the tumors were excised and HE staining was performed. The binding radioactivity (sum of membrane-bound and internalized radioligand) of A549-hSSTR2 cells was 18.24 ± 1.9 % of total counts added after 1 h of incubation, and was higher than that of A549-pcDNA3 cells 5.7 ± 1.4 % (P < 0.05). The inhibition ratio of A549-hSSTR2 cells was 78.8 ± 5.9 %. Clear images of tumor lesions in nude mice were achieved at 0.5 h post injection. In the A549-hSSTR2 xenograft tumor group, the growth of the tumors treated with $^{131}$I-RC-160 was significantly inhibited as compared to tumors in the group treated with RC-160 (P < 0.01). This study demonstrated that it was possible to introduce hsstr2 to non-expressing tumor cell lines and treat tumors with radiolabeled somatostatin analogs.
Starting Page	2451
Ending Page	2457
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-04-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Somatostatin Receptor imaging Lung cancer Gene therapy Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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