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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jin, Ke Xiang, Yonghua Tang, Jing Wu, Guangchun Li, Junwei Xiao, Huaichun Li, Chunwang Chen, Yuxiang Zhao, Jingfeng |
| Copyright Year | 2013 |
| Abstract | miR-34a has been identified as a tumor suppressor in several tumors, but its involvement in gallbladder cancer (GBC) has not been reported. In this study, the miR-34a level and telomere length were measured in 77 gallbladder adenocarcinomas and 36 peritumoral tissues by real-time PCR. Forced miR-34a expression was established by an adenovirus carrying a miR-34a expression cassette. The colony-forming ability of isolated CD44$^{+}$CD133$^{+}$ GBC tumor stem-like cells was measured by matrigel colony assay. The xenograft tumor models were established by inoculating nude mice with CD44$^{+}$CD133$^{+}$cells. Results showed that significantly lower miR-34a expression and longer telomere length were observed in gallbladder adenocarcinoma tissues, which correlated with poor prognosis of GBC patients. Forced overexpression of miR-34a inhibited the colony-forming ability of CD44$^{+}$CD133$^{+}$ GBC tumor stem-like cells in vitro and xenograft tumor growth in vivo. Injection of Ad-miR-34a downregulated PNUTS expression and reduced telomere length in xenograft GBC tumor cells. In conclusion, miR-34a is a tumor suppressor in gallbladder cancer. Both low miR-34a expression and long telomere length are markers for poor prognosis of patients with gallbladder adenocarcinoma. Our study also suggests that the miR-34a gene could be a target for targeting therapy of GBC. |
| Starting Page | 1503 |
| Ending Page | 1510 |
| Page Count | 8 |
| File Format | |
| ISSN | 10104283 |
| Journal | Tumor Biology |
| Volume Number | 35 |
| Issue Number | 2 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-09-28 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Gallbladder cancer miR-34a Telomere length Prognosis Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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