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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chiranjeevi, P. Spurthi, K. Mrudula Rani, N. Santhoshi Kumar, G. Rajesh Aiyengar, T. Mohini Saraswati, M. Srilatha, G. Kumar, G. Kishore Sinha, Sudha Kumari, C. Sanjeeva Reddy, B. Nagarjuna Vishnupriya, S. Rani, H. Surekha |
| Copyright Year | 2013 |
| Abstract | Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the basement membrane. Our study aims to examine the association of Gelatinase B (−1562C > T) promoter polymorphism with breast cancer invasion and progression. The study involves 200 breast cancer patients and age-matched 191 healthy controls. The SNP-1562C > T (rs3918242) in MMP-9 promoter region was examined by allele-specific polymerase chain reaction and gel electrophoresis. The genotypes were determined and compared between patients and controls, and the influence of the polymorphism on clinicopathological data was analyzed. The T allele of the -1562C > T MMP-9 polymorphism was detected more frequently in breast cancer patients than controls (p < 0.001). Our results suggest the clinical importance of MMP-9 gene polymorphism (−1562C > T) in breast cancer patients. The study may also help in identifying individuals at risk of developing breast cancer. |
| Starting Page | 1351 |
| Ending Page | 1356 |
| Page Count | 6 |
| File Format | |
| ISSN | 10104283 |
| Journal | Tumor Biology |
| Volume Number | 35 |
| Issue Number | 2 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-12-20 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Breast cancer Tumor invasion Allele specific Genotyping Matrix metalloproteinases MMP-9 gene Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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