NDLI: Lymphopenia during routine follow-up may predict relapse in patients with extranodal NK/T cell lymphoma

Content Provider	Springer Nature Link
Author	Wang, Liang Wang, Jing hua Wu Xiao, Zhi jun Xia, Zhong jun Huang, Hui qiang Lu, Yue
Copyright Year	2014
Abstract	Recently, absolute lymphocyte count (ALC) at diagnosis, as a surrogate marker of host immunity, has been reported to be a prognostic factor for clinical outcomes in extranodal NK/T cell lymphoma (ENKTL). In this retrospective study, we set out to investigate whether ALC at the time of confirmed relapse or at last follow-up is a marker for relapse after chemoradiotherapy in 84 patients with stage I/II ENKTL. Receiver operating characteristics (ROC) curve and area under the curve (AUC) analysis showed that ALC at follow-up was a significant marker for relapse (AUC = 0.883, P < 0.001). Using 1.215 × 10$^{9}$/L as the optimal cutoff value of ALC, 44 patients (52.4 %) were in lower ALC group and 40 patients (47.6 %) were in higher ALC group. The sensitivity and specificity for ALC at the time of confirmed relapse or at last follow-up was 94.1 and 76.0 %, respectively. The relative risk of relapse with an ALC < 1.215 × 10$^{9}$/L was 14.5. The positive predictive value with an ALC < 1.215 × 10$^{9}$/L was 72.7 %, and the negative predictive value with an ALC ≥ 1.215 × 10$^{9}$/L was 95.0 %. The 4-year cumulative incidence rate for an ALC < 1.215 × 10$^{9}$/L was 73.2 % compared with 3.2 % for an ALC ≥ 1.215 × 10$^{9}$/L (P < 0.001). In a multivariate regression analysis, ALC at the time of confirmed relapse or last follow-up remained to be a significant factor for relapse (P < 0.001). In conclusion, lymphopenia observed during routine follow-up can predict relapse in patients with ENKTL, which needs further validation in prospective trials.
Starting Page	1747
Ending Page	1753
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-10-31
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Absolute lymphocyte count Lymphopenia Relapse Extranodal NK/T cell lymphoma Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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