NDLI: Polymorphisms of the receptor for advanced glycation end-products and glyoxalase I in patients with renal cancer

Content Provider	Springer Nature Link
Author	Chocholatý, Matúš Jáchymová, Marie Schmidt, Marek Havlová, Klára Křepelová, Anna Zima, Tomáš Babjuk, Marko Kalousová, Marta
Copyright Year	2014
Abstract	The receptor for advanced glycation end products (RAGE) and its ligands are involved in the pathogenesis of cancer. Glyoxalase I (GLO1) is an enzyme which detoxifies advanced glycation end product (AGE) precursors. The aim of the study was to find out the relationship between four polymorphisms (single nucleotide polymorphism, SNP) of the RAGE gene (AGER) and one SNP of the GLO1 gene and clear cell renal cancer (ccRCC). All polymorphisms (rs1800625 RAGE -429T/C, rs1800624 -374T/A, rs3134940 2184A/G, rs2070600 557G/A (G82S), and GLO1 rs4746 419A/C(E111A)) were determined by PCR-RFLP in 214 patients with ccRCC. A group of 154 healthy subjects was used as control. We found significant differences in the allelic and genotype frequencies of GLO1 E111A (419A/C) SNP between patients and controls—higher frequency of the C allele in ccRCC—58.6 vs. 44.5 % in controls, OR (95 % CI) 1.77 (1.32–2.38), p = 0.0002 (corrected p = 0.001); OR (95 % CI) CC vs. AA 2.76 (1.5–4.80), p = 0.0004 (corrected p = 0.002); and AC+CC vs. AA 2.03 (1.23–3.30), p = 0.0034 (corrected p = 0.017). High aggressiveness of the tumor (grade 4) was associated with the presence of C allele RAGE -429T/C SNP (original p = 0.001, corrected p = 0.005) and G allele RAGE 2184A/G SNP (p < 0.001 and p < 0.005), and for genotypes RAGE -429CC (original p = 0.008, corrected p = 0.04) and RAGE 2184GG SNP (original p = 0.005, corrected p = 0.025). Our results demonstrate the link of E111A GLO1 SNP to the presence of the tumor and the connection of RAGE -429T/C and 2184A/G SNPs with the aggressiveness of the tumor. Further studies are required, especially with respect to potential therapeutic implications.
Starting Page	2121
Ending Page	2126
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-11-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Receptor for advanced glycation end products RAGE Gloyxalase I GLO1 Renal cell cancer Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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