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Genotoxicity studies of substance-P by using short-term assay

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Genotoxicity studies of substance-P by using short-term assay

Content Provider	Springer Nature Link
Author	Hong, Hyun Sook Yim, Sung Vin Son, Youngsook
Copyright Year	2016
Abstract	Substance-P (SP) can function of mobilizing mesenchymal stem cells (MSCs) from the bone marrow to the circulation and exert anti-inflammatory effects by increasing anti-inflammatory M2-type macrophage and regulatory T cells in the circulation. The preclinical efficacy of SP was demonstrated in a variety of conditions including ischemia damages, but its safety was not assessed. In this study, we assessed the genotoxicity of SP by using in vitro bacterial reverse mutation assay, chromosomal aberration assay, and in vivo micronucleus test. The maximum test dose of SP was 250 μg/mL in a cell-based assay and 16.6 mg/kg for an in vivo test. Ames test revealed SP did not increase in the number of revertant colonies. An in vitro chromosomal aberration assay with Chinese hamster lung cells showed that SP was not clastogenic even at the maximum dose applied. In vivo micronucleus test also demonstrated that SP did not induce micronuclei formation in the bone marrow cells of male ICR mice. Taken together, our results suggest that SP is not mutagenic to bacterial cells. Moreover, SP does not cause chromosomal damage in mammalian cells either in vitro or in vivo.
Starting Page	447
Ending Page	452
Page Count	6
File Format	PDF
ISSN	1738642X
Journal	Molecular & Cellular Toxicology
Volume Number	12
Issue Number	4
e-ISSN	20928467
Language	English
Publisher	The Korean Society of Toxicogenomics and Toxicoproteomics
Publisher Date	2017-01-07
Publisher Place	Incheon
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Substance-P Chromosomal aberration test Micronucleus assay Ames test Genotoxicity Cell Biology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine

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Genotoxicity studies of substance-P by using short-term assay

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