NDLI: Genotoxic evaluation of tert-butyl methacrylate for workers’ health with bacterial reverse mutation (Ames) and in vitro mammalian chromosomal aberration assay

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Oxidative stress status, caspase-3, stromal enzymes and mitochondrial respiration and swelling of Paramecium caudatum in responding to the toxicity of Fe$_{3}$O$_{4}$ nanoparticles

Genotoxic evaluation of tert-butyl methacrylate for workers’ health with bacterial reverse mutation (Ames) and in vitro mammalian chromosomal aberration assay

Transcriptional responses in Ecklonia cava to short-term exposure to hyperthermal stress

Toxicology and Environmental Health Sciences : Volume 8, Issue 1, March 2016

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Genotoxic evaluation of tert-butyl methacrylate for workers’ health with bacterial reverse mutation (Ames) and in vitro mammalian chromosomal aberration assay

Content Provider	Springer Nature Link
Author	Rim, Kyung Taek Kim, Soo Jin
Copyright Year	2016
Abstract	Chemical hazard evaluations are important for work-ers’ health and working environments. tert-Butyl methacrylate (CAS No. 585-07-9) is used in many in-dustries, leading to concerns about the possibility of threats to the health of workers. Since only insufficient or controversial information is available about potential related hazards, Ames assay and in vitro mammalian chromosomal aberration (CA) assay were conducted in order to gain additional information concerning any such hazards. Moreover, toxicologi- cal information from this study could be applied for workers’ rights as background knowledge, and for the preparation or update of the Materials Safety Data Sheet (MSDS) for a number of industries. In this Ames reverse mutation study, treatment of 1,250, 625, 312.5, 156.25, 78.125 pg/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, or in Escherichia coli WP2uvrA with and without metabolic activation. In vitro chromosomal aberration assay was performed using the Chinese hamster lung fibroblast cell (ATCC, CRL-1935) by the direct method (− S9) and by the metabolic activated method (+S9 mix) at a dose of 0.039, 0.078, 0.156, 0.312, 0.625, 1.25, 2.5 mg/mL. Using the direct method, the seven dosages in the 48-hour treatment group did not show that the frequency of CA was proportional to the dosage. The frequency of CA is not proportional to the dosage addition for a six-hour treatment using the metabolic activated method. From these findings, the chemical does not have mutagenic potential under the conditions of the Ames assay, but also does not induce chromosomal aberrations under the tested conditions. However, further investigations are necessary because it may be harmful to workers after ingestion, inhalation, skin or eye contact. It is also desirable to prepare a local exhaust system and to wear personal protection equipment.
Starting Page	168
Ending Page	180
Page Count	13
File Format	PDF
ISSN	20059752
Journal	Toxicology and Environmental Health Sciences
Volume Number	8
Issue Number	2
e-ISSN	22337784
Language	English
Publisher	Korean Society of Environmental Risk Assessment and Health Science
Publisher Date	2016-07-19
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	tert-Butyl Methacrylate Reverse mutation Chromosomal aberration In vitro Chinese hamster lung fibroblast Pharmacology/Toxicology Environmental Health
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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