NDLI: Inhibition of Carbonic Anhydrase Reduces Brain Injury After Intracerebral Hemorrhage

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Inhibition of Carbonic Anhydrase Reduces Brain Injury After Intracerebral Hemorrhage

Content Provider	Springer Nature Link
Author	Guo, Fuyou Hua, Ya Wang, Jinhu Keep, Richard F. Xi, Guohua
Copyright Year	2011
Abstract	Carbonic anhydrase 1 (CA-1) is a metalloenzyme present at high concentrations in erythrocytes. Our previous studies showed that erythrocyte lysis contributes to brain edema formation after intracerebral hemorrhage (ICH), and a recent study indicates that CA-1 can cause blood–brain barrier disruption. The present study investigated the role of CA-1 in ICH-induced brain injury. There were three groups in the study. In the first, adult male Sprague Dawley rats received 100 μl autologous blood injection into the right caudate. Sham rats had a needle insertion. Rat brains were used for brain CA-1 level determination. In the second group, rats received an intracaudate injection of either 50 μl CA-1 (1 μg/μl) or saline. Brain water content, microglia activation, and neuronal death (Fluoro-Jade C staining) were examined 24 h later. In the third group, acetazolamide (AZA, 5 μl, 1 mM), an inhibitor of carbonic anhydrases, or vehicle was co-injected with 100 μl blood. Brain water content, neuronal death, and behavioral deficits were measured. We found that CA-I levels were elevated in the ipsilateral basal ganglia at 24 h after ICH. Intracaudate injection of CA-1 induced brain edema (79.0 ± 0.6 vs. 78.0 ± 0.2% in the saline group, p < 0.01), microglia activation, and neuronal death (p < 0.01) at 24 h. AZA, an inhibitor of CA, reduced ICH-induced brain water content (79.3 ± 0.7 vs. 81.0 ± 1.0% in the vehicle-treated group, p < 0.05), neuronal death, and improved functional outcome (p < 0.05). These results suggest that CA-1 from erythrocyte lysis contributes to brain injury after ICH.
Starting Page	130
Ending Page	137
Page Count	8
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	3
Issue Number	1
e-ISSN	1868601X
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-09-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Acetazolamide Brain edema Carbonic anhydrase 1 Cerebral hemorrhage Rats Vascular Surgery Neurosurgery Neurosciences Cardiology Neurology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

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