NDLI: Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI

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Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI

Content Provider	Springer Nature Link
Author	Zhou, Jinyuan Zijl, Peter C. M.
Copyright Year	2011
Abstract	It has been proposed that the spatial mismatch between deficits on perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) in MRI can be used to decide regarding thrombolytic treatment in acute stroke. However, uncertainty remains about the meaning and reversibility of the perfusion deficit and even part of the diffusion deficit. Thus, there remains a need for continued development of imaging technology that can better define a potentially salvageable ischemic area at risk of infarction. Amide proton transfer imaging is a novel MRI method that can map tissue pH changes, thus providing the potential to separate the PWI/DWI mismatch into an acidosis-based penumbra and a zone of benign oligemia. In this totally noninvasive method, the pH dependence of the chemical exchange between amide protons in endogenous proteins and peptides and water protons is exploited. Early results in animal models of ischemia show promise to derive an acidosis penumbra. Possible translation to the clinic and hurdles standing in the way of achieving this are discussed.
Starting Page	76
Ending Page	83
Page Count	8
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	3
Issue Number	1
e-ISSN	1868601X
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-10-28
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Penumbra Acidosis Ischemic threshold Stroke Ischemia Area at risk of infarction Salvageable tissue Perfusion/diffusion mismatch APT pH Imaging MRI Vascular Surgery Neurosurgery Neurosciences Cardiology Neurology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

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