NDLI: Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats

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Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats

Translational Stroke Research : Volume 6, Issue 3, June 2015

Translational Stroke Research : Volume 6, Issue 2, April 2015

Translational Stroke Research : Volume 6, Issue 1, February 2015

Translational Stroke Research : Volume 5

Translational Stroke Research : Volume 4

Translational Stroke Research : Volume 3

Translational Stroke Research : Volume 2

Translational Stroke Research : Volume 1

Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats

Content Provider	Springer Nature Link
Author	McBride, Devin W. Klebe, Damon Tang, Jiping Zhang, John H.
Copyright Year	2015
Abstract	Evaluating infarct volume is the primary outcome for experimental ischemic stroke studies and is a major factor in determining translation of a drug into clinical trials. Numerous algorithms are available for evaluating this critical value, but a major limitation of current algorithms is that brain swelling is not appropriately considered. The model by Lin et al. is widely used, but overestimates swelling within the infarction, yielding infarct volumes which do not reflect the true infarct size. Herein, a new infarct volume algorithm is developed to minimize the effects of both peri-infarct and infarct core swelling on infarct volume measurement. 2,3,5-Triphenyl-2H-tetrazolium chloride-stained brain tissue of adult rats subjected to middle cerebral artery occlusion was used for infarct volume analysis. When both peri-infarct swelling and infarction core swelling are removed from infarct volume calculations, such as accomplished by our algorithm, larger infarct volumes are estimated than those of Lin et al.’s algorithm. Furthermore, the infarct volume difference between the two algorithms is the greatest for small infarcts (<10 % of brain volume) when peri-infarct swelling is the greatest. Finally, using data from four published studies, our algorithm is compared to Lin et al.’s algorithm. Our algorithm offers a more reliable estimation of the infarct volume after ischemic brain injury, and thus may provide the foundation for comparing infarct volumes between experimental studies and standardizing infarct volume quantification to aid in the selection of the best candidates for clinical trials.
Starting Page	323
Ending Page	338
Page Count	16
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	6
Issue Number	4
e-ISSN	1868601X
Language	English
Publisher	Springer US
Publisher Date	2015-05-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Brain swelling Infarct volume Infarction Middle cerebral artery occlusion MCAO Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

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