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| Content Provider | Springer Nature Link |
|---|---|
| Author | McBride, Devin W. Zhang, John H. |
| Copyright Year | 2017 |
| Abstract | An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% of the treatment studies for MCAO used prompt transient MCAO models and only 36% of the studies used permanent MCAO or gradual transient MCAO (i.e., embolic stroke model). Then, in 2014 and 2015, 88% of published basic science studies on large vessel occlusion used the transient MCAO model. However, this model only represents 2.5–11.3% of large vessel stroke patients. Therefore, the transient MCAO model, which mimics stroke with reperfusion, does not accurately reflect the majority of clinical stroke cases. Thus, once again, the argument for studying permanent MCAO as a primary model is made and supported. |
| Starting Page | 397 |
| Ending Page | 404 |
| Page Count | 8 |
| File Format | |
| ISSN | 18684483 |
| Journal | Translational Stroke Research |
| Volume Number | 8 |
| Issue Number | 5 |
| e-ISSN | 1868601X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2017-07-17 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Animal models Ischemia Middle cerebral artery occlusion Reperfusion Stroke Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical) |
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