NDLI: Recombinant T Cell Receptor Ligands Improve Outcome After Experimental Cerebral Ischemia

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Recombinant T Cell Receptor Ligands Improve Outcome After Experimental Cerebral Ischemia

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Translational Stroke Research : Volume 2, Issue 2, June 2011

Translational Stroke Research : Volume 2, Issue 1, March 2011

Translational Stroke Research : Volume 1

Recombinant T Cell Receptor Ligands Improve Outcome After Experimental Cerebral Ischemia

Content Provider	Springer Nature Link
Author	Akiyoshi, Kozaburo Dziennis, Suzan Palmateer, Julie Ren, Xuefang Vandenbark, Arthur A. Offner, Halina Herson, Paco S. Hurn, Patricia D.
Copyright Year	2011
Abstract	A key target for novel stroke therapy is the regulation of post-ischemic inflammatory mechanisms. Recent evidence emphasizes the role of T lymphocytes of differing subtypes in the evolution is ischemic brain damage. We have recently demonstrated the benefit of myelin antigen-specific immunodulatory agents known as recombinant T cell receptor ligands (RTLs) in a standard murine model of focal stroke. The aim of the current study was to extend this initial observation to RTL treatment in a therapeutically relevant timing after middle cerebral artery occlusion (MCAO) and verify functional benefit to complement histological outcome measures. We observed that the administration of mouse-specific RTL551 reduced infarct size and improved sensorimotor outcome when administered within a 3 h post-ischemic therapeutic window. RTL551 treatment reduced cortical, caudate putamen, and total infarct volume as compared to vehicle-treated mice. Using a standard behavioral testing repertoire, we observed that RTL551 reduced sensorimotor impairment 3 days after MCAO. Humanized RTL1000 (HLA-DR2 moiety linked to hMOG-35-55 peptide) also reduced infarct size in HLA-DR2 transgenic mice. These data indicate that this neuroantigen-specific immunomodulatory agent reduces damage when administered in a therapeutically relevant reperfusion timeframe.
Starting Page	404
Ending Page	410
Page Count	7
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	2
Issue Number	3
e-ISSN	1868601X
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-05-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerebral ischemia Cerebral infarction Inflammation T lymphocyte Immunotherapy Mouse Middle cerebral artery occlusion Stroke Cardiology Neurosciences Neurology Vascular Surgery Neurosurgery
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

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