NDLI: Synthesis, Characterization and Biocompatibility Studies of Gold Nanoparticles from Zingiber officinal

Content Provider	Springer Nature Link
Author	Babu, R. L. Charanya, Shankar Biradar, Santhosh K. Goornavar, Virupaxi Jeffers, Robert Ronurpraful, Tejaswini Prabhu, Prathima T. Bowman, Arthur Hall, Joseph C. Ramesh, Govindarajan T.
Copyright Year	2017
Abstract	Synthesis of nanomaterials through eco-friendly (green) approaches has attracted much attention due to the widespread biomedical application and environmental issues. The present study describes the green synthesis of gold nanoparticles (GNPs) using rhizome suspension of ginger (Zingiber officinale). The formation of GNPs was visually observed in a sample by color change from colorless to purple; further, the green synthesis process was optimized for improved production of GNPs with the suspension to chloroauric acid ratio (1:10). The synthesized GNPs were characterized by FESEM, EDX, and TEM. Ginger-based GNP synthesis gave particles of >20 nm in size. The GNPs were largely found to be spherical in shape and stable at room temperature. A live/dead cell viability assay conducted on lung epithelial cells revealed the safe nature of GNP materials up to 25 μg/ml. These results were correlated by MTT assay. It is also observed that there was no significant elevation in reactive oxygen species (ROS) level in GNP-treated lung epithelial cells (BEAS-2B). Biocompatibility studies of GNPs also revealed the negligible cytotoxicity and validate the safe nature, and no induction of oxidative stress. Collectively, these observations suggest the involvement of phytochemicals from the ginger. Future manipulation of these GNPs offers commercial benefits, particularly for biomedical applications like diagnostics and therapeutics.
Starting Page	558
Ending Page	564
Page Count	7
File Format	PDF
ISSN	21911630
Journal	BioNanoScience
Volume Number	7
Issue Number	4
e-ISSN	21911649
Language	English
Publisher	Springer US
Publisher Date	2017-06-23
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gold nanoparticles Chloroauric acid Lung epithelial cells MTT assay Reactive oxygen species Biocompatibility Circuits and Systems Biological and Medical Physics, Biophysics Nanotechnology Biomaterials
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering

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