NDLI: Hyperfibrinogenemia and Increased Stiffness of Plasma Clots in the Active Systemic Lupus Erythematosus

Content Provider	Springer Nature Link
Author	Zubairova, L. D. Nabiullina, R. M. Shakurova, M. A. Sibgatullin, T. B. Maksudova, A. N. Litvinov, R. I.
Copyright Year	2017
Abstract	Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an increased risk of thrombosis. We hypothesized that inflammation-associated hyperfibrinogenemia can contribute to the prothrombotic phenotype of fibrin clots by changing their mechanical properties. Twenty-eight SLE patients were categorized based on their disease activity scores (SLEDAI) into the groups with inactive (SLEDAI < 4, n = 14) and active (SLEDAI > 4, n = 14) forms of the disease. Clots from individual platelet-free plasma samples were probed using shear rheometry and viscoelastic properties of the fibrin gels were determined as the storage (G′) and loss (G″) moduli. A significant increase of G′ was revealed in the clots from the plasma of active SLE patients over inactive SLE, which correlated with elevated fibrinogen levels. Clots from the plasma of inactive SLE patients had the elasticity and fibrinogen levels indistinguishable from those in control plasma from healthy subjects. Thus, inflammatory hyperfibrinogenemia in the active SLE form makes fibrin clots stiffer which has been previously shown to be associated with a higher incidence of thrombotic disorders.
Starting Page	640
Ending Page	643
Page Count	4
File Format	PDF
ISSN	21911630
Journal	BioNanoScience
Volume Number	7
Issue Number	4
e-ISSN	21911649
Language	English
Publisher	Springer US
Publisher Date	2017-08-28
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Systemic lupus erythematosus Fibrin Shear rheometry Circuits and Systems Biological and Medical Physics, Biophysics Nanotechnology Biomaterials
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering

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