NDLI: Developing translational animal models for symptoms of schizophrenia or bipolar mania

Content Provider	Springer Nature Link
Author	Geyer, Mark A.
Copyright Year	2008
Abstract	Animal models have long been used to explore hypotheses regarding the neurobiological substrates of and treatments for psychiatric disorders. Early attempts to develop models that mimic the entirety of the diagnostic syndromes in psychiatry have evolved into more appropriate efforts to model specific symptoms. Such an approach reflects the facts that even in patients, clinical symptoms transcend diagnostic categories, and the specific etiologies of psychiatric disorders are unknown. An animal model can only be identified adequately by specifying both the manipulation (drug, lesion, strain) used to induce abnormalities and the measure(s) used to characterize them. A wide range of pharmacological, lesion, and developmental manipulations have been combined with various measures of information processing to develop useful animal models that parallel human tests. Prepulse inhibition of startle, event-related potential (ERP) measures of auditory gating, and Cambridge neuropsychological test automated battery (CANTAB) measures of cognition are examples of measures that can be used in both rodents and humans and that are robustly altered in both psychiatric disorders and animals manipulated with appropriate drugs or lesions.The further development of cross-species models is critically important, given the new opportunities for the development and registration of specific treatments for the cognitive disorders of schizophrenia that are not ameliorated by available drugs. In moving beyond the focus on psychotic symptoms to the cognitive symptoms of schizophrenia, animal models that do not involve manipulations of dopamine D$_{2}$ receptors but that do utilize information processing measures that are correlated with cognitive disturbances are receiving increased attention. Here, selected examples of how cross-species measures of psychiatric disorders are developed and validated are discussed. Specific animal paradigms that parallel the specific domains of cognition that are altered in schizophrenia provide one focus of the review. Another focus includes efforts to develop new human models of psychiatric symptoms that are designed to parallel existing tests used in rodents.
Starting Page	71
Ending Page	78
Page Count	8
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	14
Issue Number	1
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Translational biomarkers Schizophrenia Bipolar mania Prepulse inhibition Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The family of sensorimotor gating disorders: Comorbidities or diagnostic overlaps?

Developmental markers of psychiatric disorders as identified by sensorimotor gating

Behavioral Perturbations After Prenatal Neurogenesis Disturbance in Female Rat

Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice

Nicotine and nicotinic system in hypoglutamatergic models of schizophrenia

Developing Translational Animal Models for Symptoms of Schizophrenia or Bipolar Mania

Adolescent Maturation of Cortical Dopamine

A neurodevelopmental model of schizophrenia: Neonatal disconnection of the hippocampus

Schizophrenia and bipolar disorder are distinguished mainly by differences in neurodevelopment

Developing translational animal models for symptoms of schizophrenia or bipolar mania

Similar Documents

The family of sensorimotor gating disorders: Comorbidities or diagnostic overlaps?

Developmental markers of psychiatric disorders as identified by sensorimotor gating

Behavioral Perturbations After Prenatal Neurogenesis Disturbance in Female Rat

Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice

Nicotine and nicotinic system in hypoglutamatergic models of schizophrenia

Developing Translational Animal Models for Symptoms of Schizophrenia or Bipolar Mania

Adolescent Maturation of Cortical Dopamine

A neurodevelopmental model of schizophrenia: Neonatal disconnection of the hippocampus

Schizophrenia and bipolar disorder are distinguished mainly by differences in neurodevelopment

Developing translational animal models for symptoms of schizophrenia or bipolar mania