NDLI: Behavioral Perturbations After Prenatal Neurogenesis Disturbance in Female Rat

Content Provider	Springer Nature Link
Author	Hazane, Franck Krebs, Marie Odile Jay, Thérèse M. Pen, Gwenaëlle
Copyright Year	2009
Abstract	The exposure to methylazoxymethanol (MAM) at embryonic day 17 (E17) results in behavioral anomalies in male rats that mimic several features of schizophrenia, including their emergence after puberty. Given that both men and women are likely to develop this illness and that currently no animal model is validated for females, we examined the behavioral consequences of E17 MAM exposure in female rats. We compared E17 MAM- and saline-exposed female rats before and/or after puberty for spontaneous activity, alternance and spatial recognition (Y-maze), spatial learning (Morris water maze), and sensory gating using the prepulse inhibition task. MAM-exposed female rats exhibited a significant increase in spontaneous locomotor activity in a novel environment, compared to sham animals, which emerged only after puberty. They also had deficits in spontaneous alternation performance and spatial recognition in a Y-maze as well as reference memory deficits in a Morris water maze task. Lastly, MAM-exposed female rats spent significantly less time in social interaction at both pre- and post-puberty and had a deficit in prepulse inhibition of the startle reflex (PPI) at adulthood. In conclusion, the present results show that, in female rat, exposure to MAM at E17 results in a pattern of behavioral changes that, on the whole, mimic positive, negative, and cognitive dimensions of schizophrenia. E17 MAM exposure thus appears to be a valid model for schizophrenia in both males and females.
Starting Page	311
Ending Page	320
Page Count	10
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	15
Issue Number	4
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-03-06
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Schizophrenia Memory Female Prepulse inhibition Methylazoxymethanol Neurobiology Pharmacology/Toxicology Neurochemistry Neurology Pharmaceutical Sciences/Technology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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