NDLI: Hepatocyte growth factor inhibits TGF-β1-induced myofibroblast differentiation in tendon fibroblasts: role of AMPK signaling pathway

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The Journal of Physiological Sciences : Volume 63, Issue 2, March 2013

The Journal of Physiological Sciences : Volume 63, Issue 1, January 2013

The Journal of Physiological Sciences : Volume 62

The Journal of Physiological Sciences : Volume 61

The Journal of Physiological Sciences : Volume 60

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Hepatocyte growth factor inhibits TGF-β1-induced myofibroblast differentiation in tendon fibroblasts: role of AMPK signaling pathway

Content Provider	Springer Nature Link
Author	Cui, Qingbo Fu, Songbin Li, Zhaozhu
Copyright Year	2013
Abstract	The transforming growth factor-β1 (TGF-β1)-induced myofibroblastic differentiation in tendon fibroblasts was thought to be one of the most important features of scar fibrosis formation, which is associated with occurrence of re-rupture. Previously, we reported that hepatocyte growth factor (HGF) inhibited TGF-β1-induced myofibroblast differentiation and extracellular matrix deposition in the Achilles tendon of rats. Here, we investigated the potential molecular mechanisms underlying the inhibitory effect of HGF on TGF-β1-induced myofibroblast differentiation. We found that treatment with HGF (10, 20, and 40 ng/ml) increased phosphorylation of adenosine monophosphate kinase (AMPK) and acetyl-CoA carboxylase (ACC) in tendon fibroblasts. Pharmacological inhibition of the AMPK signaling pathway using compound C, a specific blocker of AMPK signaling, remarkably attenuated the inhibitory effect of HGF on TGF-β1-induced myofibroblastic differentiation in tendon fibroblasts. Moreover, small interfering RNA (siRNA)-mediated knockdown of AMPKα1 subunit decreased the inhibitory effect of HGF on TGF-β1-induced myofibroblastic differentiation in tendon fibroblasts. Finally, overexpression of constitutively active AMPKα1, which led to constitutive activation of the AMPK signaling pathway in tendon fibroblasts, mimicked the inhibitory effect of HGF on the TGF-β1-induced myofibroblastic differentiation. Our study therefore suggests that HGF inhibits TGF-β1-induced myofibroblastic differentiation via an AMPK signaling pathway-dependent manner in tendon fibroblasts.
Starting Page	163
Ending Page	170
Page Count	8
File Format	PDF
ISSN	18806546
Journal	The Journal of Physiological Sciences
Volume Number	63
Issue Number	3
e-ISSN	18806562
Language	English
Publisher	Springer Japan
Publisher Date	2013-02-01
Publisher Place	Japan
Access Restriction	Subscribed
Subject Keyword	HGF TGF-β1 Myofibroblastic differentiation AMPK Human Physiology Neurosciences Animal Biochemistry Animal Physiology Cell Physiology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Physiology

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