NDLI: Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors

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Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors

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The Journal of Physiological Sciences : Volume 63, Issue 2, March 2013

The Journal of Physiological Sciences : Volume 63, Issue 1, January 2013

The Journal of Physiological Sciences : Volume 62

The Journal of Physiological Sciences : Volume 61

The Journal of Physiological Sciences : Volume 60

The Journal of Physiological Sciences : Volume 59

Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors

Content Provider	Springer Nature Link
Author	Redington, Kathrine L. Disenhouse, Tara Li, Jing Wei, Can Dai, Xiaojing Gladstone, Rachel Manlhiot, Cedric Redington, Andrew N.
Copyright Year	2013
Abstract	Previous studies have shown that electroacupuncture (EA) can induce cardioprotection against ischemia–reperfusion (IR) injury, but its mechanisms are incompletely understood. We have previously shown that several other forms of remote preconditioning of the heart work, at least in part, via the release of circulating cardioprotective factors into the bloodstream, that can be dialyzed and subsequently shown to reduce IR injury in isolated hearts. We used the same methods to assess whether EA leads to similar humoral cardioprotection. EA rabbits were subjected to 60 min of bilateral stimulation at the Neiguan point, following which their blood was drawn, dialyzed, and used to perfuse hearts in Langendorff preparation and subsequently subjected to 60 min of global ischemia and 120 min of reperfusion. Compared to controls, dialysate from EA animals led to significant reduction in infarct size and improved functional recovery. The degree of cardioprotection was no different to that seen in animals randomized to receive remote preconditioning using transient limb ischemia (4 cycles of 5 min ischemia/5 min reperfusion). These results suggest that EA recapitulates the cardioprotection achieved by remote preconditioning, by similarly leading to release of circulating cardioprotective factors.
Starting Page	219
Ending Page	223
Page Count	5
File Format	PDF
ISSN	18806546
Journal	The Journal of Physiological Sciences
Volume Number	63
Issue Number	3
e-ISSN	18806562
Language	English
Publisher	Springer Japan
Publisher Date	2013-03-26
Publisher Place	Japan
Access Restriction	Subscribed
Subject Keyword	Remote preconditioning Electroacupuncture Cardioprotection Human Physiology Neurosciences Animal Biochemistry Animal Physiology Cell Physiology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Physiology

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