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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cui, Qingbo Wang, Zhigang Jiang, Dapeng Qu, Lihui Guo, Junbin Li, Zhaozhu |
| Copyright Year | 2010 |
| Abstract | Both myofibroblast differentiation and extracellular matrix (ECM) deposition are essential components of scar formation in tendons, and hepatocyte growth factor (HGF) is reported to prevent fibrogenic responses in tendons. Matrix metalloproteinases-2(MMP-2) is also involved in the healing process in tendons. Whether HGF protects healed Achilles tendons from injury-induced scar formation and the mechanisms are unknown. Daily for 2 weeks after wounding, except for the non-surgical control group, the Achilles tendons in rats were locally injected with HGF (100 ng 50 μl−1 per mouse) or phosphate-buffered saline (PBS). Histological examination showed HGF ameliorated disorganized collagen fibers caused by surgical incisions in rats. After transforming growth factor beta-1 (TGF-β1) induced fibrogenic responses in primary Achilles tendon fibroblasts in rats, HGF treatment for 24 h reduced α-smooth muscle actin (α-SMA) (0.60 ± 0.07-fold, P < 0.05) and type III collagen expression (0.39 ± 0.07-fold, P < 0.05). Moreover, HGF elevated MMP-2 expression (1.23 ± 0.11-fold, P < 0.05). The MMP-2 inhibitor, tissue inhibitors of metalloproteinase-1 (TIMP-1), partially blocked the inhibitory effects of HGF on α-SMA expression (from 0.60 ± 0.07-fold to 0.83 ± 0.07-fold, P < 0.05) and type III collagen expression (from 0.39 ± 0.06-fold to 0.86 ± 0.08-fold, P < 0.05). These results indicate HGF attenuates TGF-β1-induced fibrogenic responses in Achilles tendon, which was mediated by MMP-2. These results will aid in developing effective therapeutic approaches for the dysfunctional repair in Achilles tendons. |
| Starting Page | 1457 |
| Ending Page | 1463 |
| Page Count | 7 |
| File Format | |
| ISSN | 14396319 |
| Journal | European Journal of Applied Physiology |
| Volume Number | 111 |
| Issue Number | 7 |
| e-ISSN | 14396327 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-12-17 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hepatocyte growth factor (HGF) Matrix metalloproteinases-2(MMP-2) Achilles tendon Transforming growth factor beta-1 (TGF-β1) Extracellular matrix (ECM) Occupational Medicine/Industrial Medicine Sports Medicine Human Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science |
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