NDLI: Expression and distribution of voltage-gated sodium channels in the cerebellum

Content Provider	Springer Nature Link
Author	Schaller, Kristin L. Caldwell, John H.
Copyright Year	2003
Abstract	In order to understand the effects of sodium channels on synaptic signaling and response in the cerebellum, it is essential to know for each class of neuron what sodium channel isoforms are present, and the properties and distribution of each. Sodium channels are heteromultimeric membrane proteins, consisting of a large alpha subunit that forms the pore, and one or more beta subunits. Ten genes encode an alpha subunit in mammals, and of these, four are expressed in the cerebellum: Na$_{v}$l.l, Na$_{v}$1.2, Na$_{v}$1.3 and Na$_{v}$1.6. Three genes encode beta subunits (Naβl–3), and all three are expressed in the cerebellum. However, Na$_{v}$1.3 and Naβ3 have been found only in the developing cerebellum. All sodium channels recorded in the cerebellum are TTX-sensitive with similar kinetics, making it difficult to identify the isoforms electrically. Thus, most of the expression studies have relied on techniques that allow visualization of sodium channel subtypes at the level of mRNA and protein. In situ hybridization and immunolocalization studies demonstrated that granule cells predominantly express Na$_{v}$1.2, Na$_{v}$1.6, Naβ1, and Naβ2. Protein for Na$_{v}$1.2 and Na$_{v}$1.6 is localized primarily in granule cell parallel fibers. Purkinje cells express Na$_{v}$1.1, Na$_{v}$1.6, Naβl and Naβ2. The somatodendritic localization of Na$_{v}$l.l and Na$_{v}$1.6 in Purkinje cells suggests that these isoforms are involved in the integration of synaptic input. Deep cerebellar nuclei neurons expressed Na$_{v}$1.1 and Na$_{v}$1.6 as well as Naβ1. Bergmann glia expressed Na$_{v}$1.6, but not granule cell layer astrocytes. Some sodium channel isoforms that are not expressed normally in the adult cerebellum are expressed in animals with mutations or disease. Electrophysiological studies suggest that Na$_{v}$1.6 is responsible for spontaneous firing and bursting features in Purkinje cells, but the specialized functions of the other subunits in the cerebellum remain unknown.
Starting Page	2
Ending Page	9
Page Count	8
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	2
Issue Number	1
e-ISSN	14734230
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	channel isoforms Purkinje cell dendrites radial glla developmental expression Neurosciences Neurobiology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression and distribution of voltage-gated sodium channels in the cerebellum

Frequency-Dependent Reliability of Spike Propagation Is Function of Axonal Voltage-Gated Sodium Channels in Cerebellar Purkinje Cells

Cerebellum-Related Characteristics of Scn8a-Mutant Mice

Polarised Localisation of the Voltage-Gated Sodium Channel Na$_{v}$1.2 in Cerebellar Granule Cells

Pannexin expression in the cerebellum

Contribution of Postsynaptic GluD2 to Presynaptic R-type Ca$^{2+}$ Channel Function, Glutamate Release and Long-term Potentiation at Parallel Fiber to Purkinje Cell Synapses

Contributions of T-Type Voltage-Gated Calcium Channels to Postsynaptic Calcium Signaling within Purkinje Neurons

Perinatal Copper Deficiency Alters Rat Cerebellar Purkinje Cell Size and Distribution

Unravelling the Purkinje neuron

Expression and distribution of voltage-gated sodium channels in the cerebellum

Similar Documents

Expression and distribution of voltage-gated sodium channels in the cerebellum

Frequency-Dependent Reliability of Spike Propagation Is Function of Axonal Voltage-Gated Sodium Channels in Cerebellar Purkinje Cells

Cerebellum-Related Characteristics of Scn8a-Mutant Mice

Polarised Localisation of the Voltage-Gated Sodium Channel Na$_{v}$1.2 in Cerebellar Granule Cells

Pannexin expression in the cerebellum

Contribution of Postsynaptic GluD2 to Presynaptic R-type Ca$^{2+}$ Channel Function, Glutamate Release and Long-term Potentiation at Parallel Fiber to Purkinje Cell Synapses

Contributions of T-Type Voltage-Gated Calcium Channels to Postsynaptic Calcium Signaling within Purkinje Neurons

Perinatal Copper Deficiency Alters Rat Cerebellar Purkinje Cell Size and Distribution

Unravelling the Purkinje neuron

Expression and distribution of voltage-gated sodium channels in the cerebellum