NDLI: Ataxia Jackson (ax $^{ J }$): a genetic model for apoptotic neuronal cell death

Content Provider	Springer Nature Link
Author	Ohgoh, Makoto Yamazaki, Kazuto
Copyright Year	2003
Abstract	Programmed cell death or apoptosis is an important process to form normal adult cytoarchitecture. But in vivo analysis of neuronal apoptosis has not been well advanced. Therefore, apoptotic cell death of a particular neuronal system or anatomical part in a mutant is an invaluable target to learn about a link between a gene and neuronal apoptosis. Ataxia (ax) is an autosomal recessive neurological mutant mouse. We recently investigated brains of homozygotes for ataxia Jackson (ax $^{ J }$), an allele of ax, using TUNEL method. A few TUNEL-positive cells were observed in the granular cell layer of the cerebellum, the dentate gyrus, and the olfactory bulb of phenotypically normal littermates (ax $^{ J }$/+ or +/+) aged at 23–38 days. In affected ax $^{ J }$/ax $^{ J }$ mice, however, the number of TUNEL-positive cells was significantly increased in the cerebellum, particularly in the granular cell layer (p < 0.05). The ax $^{ J }$ mouse will be an in vivo unique model for studies on the genetic basis of apoptotic neuronal cell death, and identification of the ax gene is desired to elucidate molecular basis of the apoptosis.
Starting Page	26
Ending Page	30
Page Count	5
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	2
Issue Number	1
e-ISSN	14734230
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ataxia mutant mouse apoptosis cerebellar granule neuron in vivo model Neurosciences Neurobiology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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