NDLI: Dynamic Changes in the Cerebellar-Interpositus/Red-Nucleus-Motoneuron Pathway During Motor Learning

Content Provider	Springer Nature Link
Author	Sánchez Campusano, Raudel Gruart, Agnès Delgado García, José M.
Copyright Year	2010
Abstract	Understanding the role played by the cerebellum in the genesis and control of learned motor responses requires a precise knowledge of interdependent relationships between kinetic neural commands and the performance (kinematics) of the acquired movements. The eyelid motor system is a useful model for studying how simple motor responses are generated and performed. Here, we recorded the activity of interpositus, red nucleus, and/or facial motor neurons during classical eyeblink conditioning, using a delay paradigm. Experiments were carried out in behaving cats, and in conscious wild-type and (Purkinje cell devoid) Lurcher mice. Kinetic variables were determined by recording the firing activities of identified neurons at the mentioned nuclei, whilst kinematic variables were selected from the electromyographic activity of the orbicularis oculi muscle and/or from eyelid position recorded during the conditioned-stimulus/unconditioned-stimulus interval. Whereas motoneurons encoded eyelid kinematics for acquired eyelid responses, interpositus, and red nucleus neurons did not directly encode eyelid performance, and the dynamic association between their neuronal activities was barely significant (from moderate to weak correlation, nonlinear coupling with high asymmetry, and neural firing activities that always lagged the beginning of the conditioned response). Nevertheless, interpositus and red nucleus neurons seem to play a modulating role in the dynamic control of this type of learned motor response, and present interesting adaptive properties in Lurcher mice. The analytical procedures proposed here could be very helpful in defining the functional state corresponding to each stage across the acquisition of new motor and cognitive abilities.
Starting Page	702
Ending Page	710
Page Count	9
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	10
Issue Number	4
e-ISSN	14734230
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-12-22
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cat Mice Classical eyeblink conditioning Facial motoneuron Red nucleus Cerebellar interpositus nucleus Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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